Effects of sleepiness on survival in japanese hemodialysis patients: J-DOPPS study

Kunitoshi Iseki, Kazuhiko Tsuruya, Eiichiro Kanda, Takanobu Nomura, Hideki Hirakata

Research output: Contribution to journalArticle

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Abstract

Sleep disorder and poor sleep quality are common in chronic hemodialysis (HD) patients. They have been claimed as a cause of morbidity and mortality. The relationship between the degree of sleepiness and survival has not been studied. We studied the degree of sleepiness in 1,252 adult HD patients (age ≥20 years) recruited into the Dialysis Outcomes Practice Pattern Study in Japan (J-DOPPS III), using the Japanese version of the Epworth Sleepiness Scale (JESS) questionnaire. Demographic data were presented for three subgroups: low, intermediate, and high JESS score. Cox proportional hazard regression analysis was performed to estimate the independent effect of several variables on survival. The hazard ratio for mortality was 2.312 (95% CI 1.267-4.220; p = 0.006) for those with a high JESS score (vs. those with a low JESS score) after adjusting for age, vintage (length of time on HD), sex, diabetes, body mass index, cardiovascular disease, HD treatment regimen (time, frequency, and single-pool Kt/V), laboratory data (serum albumin, creatinine, and total cholesterol), and medication (antihypertensive drugs, erythropoietin, vitamin D, and phosphate binders). Patients ≥70 years of age with comorbid conditions (congestive heart failure, stroke, and diabetes) showed a significantly higher JESS score (≥16). The JESS score did not show interaction by age. Results showed that the degree of sleepiness is related to survival in Japanese HD patients, particularly in elderly patients.

Original languageEnglish
Pages (from-to)333-340
Number of pages8
JournalNephron - Clinical Practice
Volume128
DOIs
Publication statusPublished - Feb 17 2014

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Renal Dialysis
Survival
Mortality
Erythropoietin
Vitamin D
Serum Albumin
Antihypertensive Agents
Dialysis
Creatinine
Japan
Sleep
Body Mass Index
Cardiovascular Diseases
Heart Failure
Stroke
Phosphates
Cholesterol
Regression Analysis
Demography
Morbidity

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Effects of sleepiness on survival in japanese hemodialysis patients : J-DOPPS study. / Iseki, Kunitoshi; Tsuruya, Kazuhiko; Kanda, Eiichiro; Nomura, Takanobu; Hirakata, Hideki.

In: Nephron - Clinical Practice, Vol. 128, 17.02.2014, p. 333-340.

Research output: Contribution to journalArticle

Iseki, Kunitoshi ; Tsuruya, Kazuhiko ; Kanda, Eiichiro ; Nomura, Takanobu ; Hirakata, Hideki. / Effects of sleepiness on survival in japanese hemodialysis patients : J-DOPPS study. In: Nephron - Clinical Practice. 2014 ; Vol. 128. pp. 333-340.
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