Effects of static magnetic fields on bone formation in rat osteoblast cultures

Y. Yamamoto, Y. Ohsaki, T. Goto, A. Nakasima, T. Iijima

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Although the promotional effects on osteoblasts of pulsed electromagnetic fields have been well-demonstrated, the effects of static magnetic fields (SMF) remain unclear; nevertheless, magnets have been clinically used as a 'force source' in various orthodontic treatments. We undertook the present investigation to study the effects of SMF on osteoblastic differentiation, proliferation, and bone nodule formation using a rat calvaria cell culture. During a 20-day culture, the values of the total area and the number and average size of bone nodules showed high levels in the presence of SMF. In the matrix development and mineralization stages, the calcium content in the matrix and two markers of osteoblastic phenotype (alkaline phosphatase and osteocalcin) also showed a significant increase. Accordingly, these findings suggest that SMF stimulates bone formation by promoting osteoblastic differentiation and/or activation.

Original languageEnglish
Pages (from-to)962-966
Number of pages5
JournalJournal of Dental Research
Volume82
Issue number12
DOIs
Publication statusPublished - Dec 2003

Fingerprint

Magnetic Fields
Osteoblasts
Osteogenesis
Electromagnetic Fields
Magnets
Osteocalcin
Orthodontics
Skull
Alkaline Phosphatase
Cell Culture Techniques
Calcium
Phenotype
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Effects of static magnetic fields on bone formation in rat osteoblast cultures. / Yamamoto, Y.; Ohsaki, Y.; Goto, T.; Nakasima, A.; Iijima, T.

In: Journal of Dental Research, Vol. 82, No. 12, 12.2003, p. 962-966.

Research output: Contribution to journalArticle

Yamamoto, Y, Ohsaki, Y, Goto, T, Nakasima, A & Iijima, T 2003, 'Effects of static magnetic fields on bone formation in rat osteoblast cultures', Journal of Dental Research, vol. 82, no. 12, pp. 962-966. https://doi.org/10.1177/154405910308201205
Yamamoto, Y. ; Ohsaki, Y. ; Goto, T. ; Nakasima, A. ; Iijima, T. / Effects of static magnetic fields on bone formation in rat osteoblast cultures. In: Journal of Dental Research. 2003 ; Vol. 82, No. 12. pp. 962-966.
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