Abstract
Although the promotional effects on osteoblasts of pulsed electromagnetic fields have been well-demonstrated, the effects of static magnetic fields (SMF) remain unclear; nevertheless, magnets have been clinically used as a 'force source' in various orthodontic treatments. We undertook the present investigation to study the effects of SMF on osteoblastic differentiation, proliferation, and bone nodule formation using a rat calvaria cell culture. During a 20-day culture, the values of the total area and the number and average size of bone nodules showed high levels in the presence of SMF. In the matrix development and mineralization stages, the calcium content in the matrix and two markers of osteoblastic phenotype (alkaline phosphatase and osteocalcin) also showed a significant increase. Accordingly, these findings suggest that SMF stimulates bone formation by promoting osteoblastic differentiation and/or activation.
| Original language | English |
|---|---|
| Pages (from-to) | 962-966 |
| Number of pages | 5 |
| Journal | Journal of Dental Research |
| Volume | 82 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2003 |
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All Science Journal Classification (ASJC) codes
- Dentistry(all)
Cite this
Effects of static magnetic fields on bone formation in rat osteoblast cultures. / Yamamoto, Y.; Ohsaki, Y.; Goto, T.; Nakasima, A.; Iijima, T.
In: Journal of Dental Research, Vol. 82, No. 12, 12.2003, p. 962-966.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of static magnetic fields on bone formation in rat osteoblast cultures
AU - Yamamoto, Y.
AU - Ohsaki, Y.
AU - Goto, T.
AU - Nakasima, A.
AU - Iijima, T.
PY - 2003/12
Y1 - 2003/12
N2 - Although the promotional effects on osteoblasts of pulsed electromagnetic fields have been well-demonstrated, the effects of static magnetic fields (SMF) remain unclear; nevertheless, magnets have been clinically used as a 'force source' in various orthodontic treatments. We undertook the present investigation to study the effects of SMF on osteoblastic differentiation, proliferation, and bone nodule formation using a rat calvaria cell culture. During a 20-day culture, the values of the total area and the number and average size of bone nodules showed high levels in the presence of SMF. In the matrix development and mineralization stages, the calcium content in the matrix and two markers of osteoblastic phenotype (alkaline phosphatase and osteocalcin) also showed a significant increase. Accordingly, these findings suggest that SMF stimulates bone formation by promoting osteoblastic differentiation and/or activation.
AB - Although the promotional effects on osteoblasts of pulsed electromagnetic fields have been well-demonstrated, the effects of static magnetic fields (SMF) remain unclear; nevertheless, magnets have been clinically used as a 'force source' in various orthodontic treatments. We undertook the present investigation to study the effects of SMF on osteoblastic differentiation, proliferation, and bone nodule formation using a rat calvaria cell culture. During a 20-day culture, the values of the total area and the number and average size of bone nodules showed high levels in the presence of SMF. In the matrix development and mineralization stages, the calcium content in the matrix and two markers of osteoblastic phenotype (alkaline phosphatase and osteocalcin) also showed a significant increase. Accordingly, these findings suggest that SMF stimulates bone formation by promoting osteoblastic differentiation and/or activation.
UR - http://www.scopus.com/inward/record.url?scp=4344701344&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4344701344&partnerID=8YFLogxK
U2 - 10.1177/154405910308201205
DO - 10.1177/154405910308201205
M3 - Article
C2 - 14630895
AN - SCOPUS:4344701344
VL - 82
SP - 962
EP - 966
JO - Journal of Dental Research
JF - Journal of Dental Research
SN - 0022-0345
IS - 12
ER -