Effects of stimulus parameters and tissue inhomogeneity on nerve excitation processes in magnetic stimulation of the brain: A simulation study

Akira Hyodo, Takehito Hayami, Seichi Tsuyama, Keiji Iramina, Shoogo Ueno

Research output: Contribution to journalArticle

Abstract

In this study, we used a computer simulation to investigate the nerve excitation processes of the nerve axon in an inhomogeneous volume conductor in magnetic stimulation. We assumed that the nerve axon was located in an inhomogeneous conducting medium with two regions having different conductivities that simulate different tissue types. The distribution of induced electric fields was calculated with the finite element method. The nerve fiber was modeled after equivalent electrical circuits having active nodes of Ranvier. We observed the excitation threshold when the coil current waveforms and direction are changed with varying the electrical properties of the tissue. The simulation results show that the threshold is lower when biphasic waveforms are used and that the optimal current direction depends on tissue conductivity. The results also suggest that the nerve is excited even when the coil current flow is perpendicular to the axon in inhomogeneous conducting media. The results in this study give useful information to explain the experimental results in magnetic stimulation of the brain.

Original languageEnglish
Article number07B304
JournalJournal of Applied Physics
Volume105
Issue number7
DOIs
Publication statusPublished - Apr 27 2009

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nerves
stimulation
axons
stimuli
brain
inhomogeneity
conductors
excitation
waveforms
coils
simulation
nerve fibers
conductivity
thresholds
finite element method
computerized simulation
electrical properties
electric fields

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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Effects of stimulus parameters and tissue inhomogeneity on nerve excitation processes in magnetic stimulation of the brain : A simulation study. / Hyodo, Akira; Hayami, Takehito; Tsuyama, Seichi; Iramina, Keiji; Ueno, Shoogo.

In: Journal of Applied Physics, Vol. 105, No. 7, 07B304, 27.04.2009.

Research output: Contribution to journalArticle

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