Effects of sulpiride treatment on the levels of immunoreactive β-endorphin in rat hypothalamic nuclei

Akito Nohtomi, Masatoshi Itoh, Nobuo Yufu

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The effects of sulpiride, a specific dopamine receptor antagonist, on the levels of immunoreactive β-endorphin (ir-β-END) in discrete hypothalamic nuclei of rats were investigated. Single injections of sulpiride significantly decreased the levels of ir-β-END in the nucleus arcuatus, nucleus paraventricularis and median eminence. Repeated injections of sulpiride significantly increased the levels of ir-β-END in the nucleus arcuatus, nucleus periventricularis and median eminence. These findings suggest that β-endorphinergic neurons are under dopaminergic control.

Original languageEnglish
Pages (from-to)152-156
Number of pages5
JournalBrain Research
Volume300
Issue number1
DOIs
Publication statusPublished - May 21 1984
Externally publishedYes

Fingerprint

Endorphins
Sulpiride
Median Eminence
Injections
Dopamine Antagonists
Dopaminergic Neurons
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

Cite this

Effects of sulpiride treatment on the levels of immunoreactive β-endorphin in rat hypothalamic nuclei. / Nohtomi, Akito; Itoh, Masatoshi; Yufu, Nobuo.

In: Brain Research, Vol. 300, No. 1, 21.05.1984, p. 152-156.

Research output: Contribution to journalArticle

Nohtomi, Akito ; Itoh, Masatoshi ; Yufu, Nobuo. / Effects of sulpiride treatment on the levels of immunoreactive β-endorphin in rat hypothalamic nuclei. In: Brain Research. 1984 ; Vol. 300, No. 1. pp. 152-156.
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