TY - JOUR
T1 - Effects of tacrolimus (FK506) on the development of osteonecrosis in a rabbit model
AU - Miyanishi, Keita
AU - Yamamoto, Takuaki
AU - Irisa, Takahiko
AU - Yamashita, Akihisa
AU - Motomura, Goro
AU - Jingushi, Seiya
AU - Iwamoto, Yukihide
N1 - Funding Information:
This research was supported by research funds to promote the hospital functions of Japan Labour Health and Welfare Organization, a Grant of Japan Orthopaedics and Traumatology Foundation, Inc. (No. 0165), and a Grant for Intractable Diseases from the Ministry of Health and Welfare of Japan.
PY - 2008/3
Y1 - 2008/3
N2 - The present study examined the effects of tacrolimus (FK506) on the development of osteonecrosis in rabbits. In Experiment A, rabbits were given FK506, and also given a single dose of steroid. Control rabbits were given the same dose of steroid only. In Experiment B, rabbits were given FK506 and a reduced dose of steroid. The results showed that addition of FK506 did not change the number of rabbits with osteonecrosis when an identical steroid dose was given. When the steroid dose was reduced, the osteonecrosis incidence significantly decreased (p < 0.01). These results suggest that the clinically reported decrease in the osteonecrosis incidence following the introduction of FK506 is most likely attributable to the lower doses of steroids.
AB - The present study examined the effects of tacrolimus (FK506) on the development of osteonecrosis in rabbits. In Experiment A, rabbits were given FK506, and also given a single dose of steroid. Control rabbits were given the same dose of steroid only. In Experiment B, rabbits were given FK506 and a reduced dose of steroid. The results showed that addition of FK506 did not change the number of rabbits with osteonecrosis when an identical steroid dose was given. When the steroid dose was reduced, the osteonecrosis incidence significantly decreased (p < 0.01). These results suggest that the clinically reported decrease in the osteonecrosis incidence following the introduction of FK506 is most likely attributable to the lower doses of steroids.
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U2 - 10.1080/08923970701812647
DO - 10.1080/08923970701812647
M3 - Article
C2 - 18306106
AN - SCOPUS:39749109663
VL - 30
SP - 79
EP - 90
JO - Immunopharmacology and Immunotoxicology
JF - Immunopharmacology and Immunotoxicology
SN - 0892-3973
IS - 1
ER -