Effects of tacrolimus (FK506) on the development of osteonecrosis in a rabbit model

Keita Miyanishi; Takuaki Yamamoto; Takahiko Irisa; Akihisa Yamashita; Goro Motomura; Seiya Jingushi; Yukihide Iwamoto

doi:10.1080/08923970701812647

Effects of tacrolimus (FK506) on the development of osteonecrosis in a rabbit model

Keita Miyanishi, Takuaki Yamamoto, Takahiko Irisa, Akihisa Yamashita, Goro Motomura, Seiya Jingushi, Yukihide Iwamoto

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The present study examined the effects of tacrolimus (FK506) on the development of osteonecrosis in rabbits. In Experiment A, rabbits were given FK506, and also given a single dose of steroid. Control rabbits were given the same dose of steroid only. In Experiment B, rabbits were given FK506 and a reduced dose of steroid. The results showed that addition of FK506 did not change the number of rabbits with osteonecrosis when an identical steroid dose was given. When the steroid dose was reduced, the osteonecrosis incidence significantly decreased (p < 0.01). These results suggest that the clinically reported decrease in the osteonecrosis incidence following the introduction of FK506 is most likely attributable to the lower doses of steroids.

Original language	English
Pages (from-to)	79-90
Number of pages	12
Journal	Immunopharmacology and Immunotoxicology
Volume	30
Issue number	1
DOIs	https://doi.org/10.1080/08923970701812647
Publication status	Published - Mar 2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Toxicology
Pharmacology

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10.1080/08923970701812647

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title = "Effects of tacrolimus (FK506) on the development of osteonecrosis in a rabbit model",

abstract = "The present study examined the effects of tacrolimus (FK506) on the development of osteonecrosis in rabbits. In Experiment A, rabbits were given FK506, and also given a single dose of steroid. Control rabbits were given the same dose of steroid only. In Experiment B, rabbits were given FK506 and a reduced dose of steroid. The results showed that addition of FK506 did not change the number of rabbits with osteonecrosis when an identical steroid dose was given. When the steroid dose was reduced, the osteonecrosis incidence significantly decreased (p < 0.01). These results suggest that the clinically reported decrease in the osteonecrosis incidence following the introduction of FK506 is most likely attributable to the lower doses of steroids.",

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AU - Miyanishi, Keita

AU - Yamamoto, Takuaki

AU - Irisa, Takahiko

AU - Yamashita, Akihisa

AU - Motomura, Goro

AU - Jingushi, Seiya

AU - Iwamoto, Yukihide

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