Effects of the adenosine A1 receptor agonist N6-cyclopentyladenosine on phencyclidine-induced behavior and expression of the immediate-early genes in the discrete brain regions of rats

Leo Gotoh, Noriko Kawanami, Tatsuo Nakahara, Hisao Hondo, Keisuke Motomura, Eiko Ohta, Izumi Kanchiku, Toshihide Kuroki, Makoto Hirano, Hideyuki Uchimura

Research output: Contribution to journalArticle

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Abstract

Because of the possible interaction between adenosine receptors and dopaminergic functions, the compound acting on the specific adenosine receptor subtype may be a candidate for novel antipsychotic drugs. To elucidate the antipsychotic potential of the selective adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA), we examined herein the effects of CPA on phencyclidine (PCP)-induced behavior and expression of the immediate-early genes (IEGs), arc, c-fos and jun B, in the discrete brain regions of rats. PCP (7.5 mg/kg, s.c.) increased locomotor activity and head weaving in rats and this effect was significantly attenuated by pretreatment with CPA (0.5 mg/kg, s.c.). PCP increased the mRNA levels of c-fos and jun B in the medial prefrontal cortex, nucleus accumbens and posterior cingulate cortex, while leaving the striatum and hippocampus unaffected. CPA pretreatment significantly attenuated the PCP-induced increase in c-fos mRNA levels in the medial prefrontal cortex and nucleus accumbens. CPA also significantly attenuated the PCP-induced arc expression in the medial prefrontal cortex and posterior cingulate cortex. When administered alone, CPA decreased the mRNA levels of all IEGs examined in the nucleus accumbens, but not in other brain regions. Based on the ability of CPA to inhibit PCP-induced hyperlocomotion and its interaction with neural systems in the medial prefrontal cortex, posterior cingulate cortex and nucleus accumbens, the present results provide further evidence for a significant antipsychotic effect of the adenosine A1 receptor agonist.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalMolecular Brain Research
Volume100
Issue number1-2
DOIs
Publication statusPublished - Apr 30 2002

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Adenosine A1 Receptor Agonists
Phencyclidine
Immediate-Early Genes
Nucleus Accumbens
Prefrontal Cortex
Gyrus Cinguli
Antipsychotic Agents
Purinergic P1 Receptors
Brain
Messenger RNA
Aptitude
Locomotion
Hippocampus
Head
N(6)-cyclopentyladenosine

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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Effects of the adenosine A1 receptor agonist N6-cyclopentyladenosine on phencyclidine-induced behavior and expression of the immediate-early genes in the discrete brain regions of rats. / Gotoh, Leo; Kawanami, Noriko; Nakahara, Tatsuo; Hondo, Hisao; Motomura, Keisuke; Ohta, Eiko; Kanchiku, Izumi; Kuroki, Toshihide; Hirano, Makoto; Uchimura, Hideyuki.

In: Molecular Brain Research, Vol. 100, No. 1-2, 30.04.2002, p. 1-12.

Research output: Contribution to journalArticle

Gotoh, Leo ; Kawanami, Noriko ; Nakahara, Tatsuo ; Hondo, Hisao ; Motomura, Keisuke ; Ohta, Eiko ; Kanchiku, Izumi ; Kuroki, Toshihide ; Hirano, Makoto ; Uchimura, Hideyuki. / Effects of the adenosine A1 receptor agonist N6-cyclopentyladenosine on phencyclidine-induced behavior and expression of the immediate-early genes in the discrete brain regions of rats. In: Molecular Brain Research. 2002 ; Vol. 100, No. 1-2. pp. 1-12.
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