Effects of the carbonate content in carbonate apatite on bone replacement

Kaai Deguchi; Shunsuke Nomura; Akira Tsuchiya; Ichiro Takahashi; Kunio Ishikawa

doi:10.1002/term.3270

Effects of the carbonate content in carbonate apatite on bone replacement

Kaai Deguchi, Shunsuke Nomura, Akira Tsuchiya, Ichiro Takahashi, Kunio Ishikawa

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Carbonate apatite (CO₃Ap), an inorganic component of human bone, has been clinically applied as an artificial bone substitute. In this study, the effects of the CO₃ content in CO₃Ap on the replacement by new bone were studied by fabricating CO₃Ap granules containing 0.9–8.3 wt% of CO₃. The dissolution rate of CO₃Ap in a weak acidic solution, mimicking the Howship's lacunae, was rapid for the CO₃Ap granules containing a larger amount of CO₃. Histological analyses demonstrated the rapid resorption in CO₃Ap and replacement by natural bone tissue when the CO₃ content was increased. Therefore, the CO₃ content in CO₃Ap is a key factor that influences the replacement of the bone tissue.

Original language	English
Pages (from-to)	200-206
Number of pages	7
Journal	Journal of Tissue Engineering and Regenerative Medicine
Volume	16
Issue number	2
DOIs	https://doi.org/10.1002/term.3270
Publication status	Published - Feb 2022

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Biomaterials
Biomedical Engineering

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title = "Effects of the carbonate content in carbonate apatite on bone replacement",

abstract = "Carbonate apatite (CO3Ap), an inorganic component of human bone, has been clinically applied as an artificial bone substitute. In this study, the effects of the CO3 content in CO3Ap on the replacement by new bone were studied by fabricating CO3Ap granules containing 0.9–8.3 wt% of CO3. The dissolution rate of CO3Ap in a weak acidic solution, mimicking the Howship's lacunae, was rapid for the CO3Ap granules containing a larger amount of CO3. Histological analyses demonstrated the rapid resorption in CO3Ap and replacement by natural bone tissue when the CO3 content was increased. Therefore, the CO3 content in CO3Ap is a key factor that influences the replacement of the bone tissue.",

author = "Kaai Deguchi and Shunsuke Nomura and Akira Tsuchiya and Ichiro Takahashi and Kunio Ishikawa",

note = "Funding Information: This work was supported by AMED under Grant Number JP21im0502004h and JSPS KAKENHI Grant Number 21K09935. Publisher Copyright: {\textcopyright} 2021 John Wiley & Sons Ltd.",

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T1 - Effects of the carbonate content in carbonate apatite on bone replacement

AU - Deguchi, Kaai

AU - Nomura, Shunsuke

AU - Tsuchiya, Akira

AU - Takahashi, Ichiro

AU - Ishikawa, Kunio

PY - 2022/2

Y1 - 2022/2

N2 - Carbonate apatite (CO3Ap), an inorganic component of human bone, has been clinically applied as an artificial bone substitute. In this study, the effects of the CO3 content in CO3Ap on the replacement by new bone were studied by fabricating CO3Ap granules containing 0.9–8.3 wt% of CO3. The dissolution rate of CO3Ap in a weak acidic solution, mimicking the Howship's lacunae, was rapid for the CO3Ap granules containing a larger amount of CO3. Histological analyses demonstrated the rapid resorption in CO3Ap and replacement by natural bone tissue when the CO3 content was increased. Therefore, the CO3 content in CO3Ap is a key factor that influences the replacement of the bone tissue.

AB - Carbonate apatite (CO3Ap), an inorganic component of human bone, has been clinically applied as an artificial bone substitute. In this study, the effects of the CO3 content in CO3Ap on the replacement by new bone were studied by fabricating CO3Ap granules containing 0.9–8.3 wt% of CO3. The dissolution rate of CO3Ap in a weak acidic solution, mimicking the Howship's lacunae, was rapid for the CO3Ap granules containing a larger amount of CO3. Histological analyses demonstrated the rapid resorption in CO3Ap and replacement by natural bone tissue when the CO3 content was increased. Therefore, the CO3 content in CO3Ap is a key factor that influences the replacement of the bone tissue.

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Effects of the carbonate content in carbonate apatite on bone replacement

Abstract

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