Effects of the Chinese Yi-Qi-Bu-Shen Recipe extract on brainstem auditory evoked potential in rats with diabetes

De Shan Liu, Wei Gao, Wei Wei Lin, Yuan Yuan Hao, Li Hong Zhong, Wei Li, Toyoshi Inoguchi, Ryoichi Takayanagi

    Research output: Contribution to journalArticle

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    Abstract

    This study was designed to investigate the effects of the Chinese Yi-Qi-Bu-Shen Recipe (YB) on brain stem auditory evoked potential (BAEP) in diabetic rats and on the protection of the diabetic rat brain's functional lesion. Thirty-three male rats were randomly divided into three groups: the normal control group (NC), the diabetic group (DM), and the diabetic rats treated with YB group (DM + YB). Blood glucose and body weight were measured every three weeks. After six weeks, the serum insulin, blood biochemical indices, superoxide dismutase, malondialdehyde, monoamine neurotransmitters, and BAEP were measured. Compared with the NC group, the waves III, V PLs, and the I-III, I-V IPLs of BAEP in the DM group were significantly delayed (all P < 0.05). However, YB-treated diabetic rats maintained a normal brainstem function over the experimental period. Compared with the NC group, the waves I, III, V PL, and waves I-III, III-V and I-V IPLs of BAEP in the DM + YB group were very close (all P > 0.05). On the other hand, compared with the DM group, the III, V PLs and the I-III, I-V IPLs of BAEP in the DM + YB group were significantly improved. It was discovered that the central conduction time of rats with diabetes had a close correlation with serum insulin, blood glucose, malondialdehyde, and insulin resistance index. Our results suggest that YB extract has a beneficial effect in preserving the brain's electrophysiological function in diabetic rats, likely through its antihyperglycemic activity, ability to reduce insulin resistance, and antioxidant activity.

    Original languageEnglish
    Pages (from-to)414-420
    Number of pages7
    JournalJournal of Ethnopharmacology
    Volume137
    Issue number1
    DOIs
    Publication statusPublished - Sep 1 2011

    Fingerprint

    Brain Stem Auditory Evoked Potentials
    Malondialdehyde
    Insulin Resistance
    Blood Glucose
    Insulin
    Control Groups
    Brain
    Serum
    Hypoglycemic Agents
    Superoxide Dismutase
    Neurotransmitter Agents
    yi-qi-bu-shen
    Antioxidants
    Body Weight

    All Science Journal Classification (ASJC) codes

    • Pharmacology
    • Drug Discovery

    Cite this

    Effects of the Chinese Yi-Qi-Bu-Shen Recipe extract on brainstem auditory evoked potential in rats with diabetes. / Liu, De Shan; Gao, Wei; Lin, Wei Wei; Hao, Yuan Yuan; Zhong, Li Hong; Li, Wei; Inoguchi, Toyoshi; Takayanagi, Ryoichi.

    In: Journal of Ethnopharmacology, Vol. 137, No. 1, 01.09.2011, p. 414-420.

    Research output: Contribution to journalArticle

    Liu, DS, Gao, W, Lin, WW, Hao, YY, Zhong, LH, Li, W, Inoguchi, T & Takayanagi, R 2011, 'Effects of the Chinese Yi-Qi-Bu-Shen Recipe extract on brainstem auditory evoked potential in rats with diabetes', Journal of Ethnopharmacology, vol. 137, no. 1, pp. 414-420. https://doi.org/10.1016/j.jep.2011.05.033
    Liu, De Shan ; Gao, Wei ; Lin, Wei Wei ; Hao, Yuan Yuan ; Zhong, Li Hong ; Li, Wei ; Inoguchi, Toyoshi ; Takayanagi, Ryoichi. / Effects of the Chinese Yi-Qi-Bu-Shen Recipe extract on brainstem auditory evoked potential in rats with diabetes. In: Journal of Ethnopharmacology. 2011 ; Vol. 137, No. 1. pp. 414-420.
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    abstract = "This study was designed to investigate the effects of the Chinese Yi-Qi-Bu-Shen Recipe (YB) on brain stem auditory evoked potential (BAEP) in diabetic rats and on the protection of the diabetic rat brain's functional lesion. Thirty-three male rats were randomly divided into three groups: the normal control group (NC), the diabetic group (DM), and the diabetic rats treated with YB group (DM + YB). Blood glucose and body weight were measured every three weeks. After six weeks, the serum insulin, blood biochemical indices, superoxide dismutase, malondialdehyde, monoamine neurotransmitters, and BAEP were measured. Compared with the NC group, the waves III, V PLs, and the I-III, I-V IPLs of BAEP in the DM group were significantly delayed (all P < 0.05). However, YB-treated diabetic rats maintained a normal brainstem function over the experimental period. Compared with the NC group, the waves I, III, V PL, and waves I-III, III-V and I-V IPLs of BAEP in the DM + YB group were very close (all P > 0.05). On the other hand, compared with the DM group, the III, V PLs and the I-III, I-V IPLs of BAEP in the DM + YB group were significantly improved. It was discovered that the central conduction time of rats with diabetes had a close correlation with serum insulin, blood glucose, malondialdehyde, and insulin resistance index. Our results suggest that YB extract has a beneficial effect in preserving the brain's electrophysiological function in diabetic rats, likely through its antihyperglycemic activity, ability to reduce insulin resistance, and antioxidant activity.",
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    AU - Zhong, Li Hong

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    AU - Takayanagi, Ryoichi

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