Effects of the L/N-type calcium channel antagonist cilnidipine on morning blood pressure control and peripheral edema formation

Sumito Narita, Yasuko Yoshioka, Atsumi Ide, Toshiaki Kadokami, Hidetoshi Momii, Masayoshi Yoshida, Shin Ichi Ando

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The L/N-type calcium channel blocker cilnidipine has unique effects including sympathetic nerve suppression and the balanced vasodilatation of arteries and veins that may alleviate morning hypertension (MHT) or peripheral edema caused by calcium channel antagonists. We used ambulatory blood pressure monitoring (ABPM) and a unique peripheral edema measurement to evaluate the effect of morning and bedtime cilnidipine in patients with MHT. Forty-three patients with MHT (60 ± 12 years) were randomly assigned to a morning or bedtime cilnidipine (10-20 mg/day). MHT was defined as a mean systolic blood pressure (SBP) ≥ 135 mm Hg by ABPM within 2 hours after awaking. After 3 months, greater SBP reductions were observed in the bedtime administration group (versus the morning administration group) at 3:30-6:00 AM (-24 ± 20 mm Hg vs. -10 ± 4 mm Hg; P <.05) and at 6:30-9:00 AM (-26 ± 15 mm Hg vs. -14 ± 17 mm Hg; P <.05). Although physical examinations showed leg edema in 16% of the patients, quantitative evaluations did not reveal significant volume gains. Cilnidipine had a greater effect on MHT, without causing significant leg edema, when administered at bedtime.

Original languageEnglish
Pages (from-to)410-416
Number of pages7
JournalJournal of the American Society of Hypertension
Volume5
Issue number5
DOIs
Publication statusPublished - Sep 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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