Effects of the non-competitive NMDA receptor antagonist ifenprodil on the morphine-induced place preference in mice

Tsutomu Suzuki, Hideaki Kato, Makoto Tsuda, Hajime Suzuki, Miwa Misawa

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The effects of ifenprodil, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, on the morphine-induced place preference were examined in mice. Morphine (1-5 mg/kg, s.c.) produced a dose-related place preference in mice. In contrast, ifenprodil alone (5-20 mg/kg, i.p.) did not produce either preference or aversion for the drug-associated place. Pretreatment with ifenprodil (5-20 mg/kg, i.p.) suppressed the place preference produced by morphine in a dose-dependent manner. These results indicate that ifenprodil suppresses the rewarding effect produced by morphine.

Original languageEnglish
Pages (from-to)PL151-PL156
JournalLife Sciences
Volume64
Issue number12
DOIs
Publication statusPublished - Feb 12 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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