Effects of the non-competitive NMDA receptor antagonist ketamine on morphine-induced place preference in mice

Tsutomu Suzuki, Hideaki Kato, Takeshi Aoki, Tsuda Makoto, Minoru Narita, Miwa Misawa

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The effects of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, on morphine-induced place preference were examined in mice. Morphine (1-5 mg/kg, s.c.)produced a dose-related place preference in mice. Ketamine alone (3, 10 mg/kg, i.p.), like dizocilpine alone (0.2 mg/kg, i.p.), also produced a preference for the drug-associated place. Pretreatment with ketamine (10 mg/kg, i.p.) or dizocilpine (0.1 and 0.2 mg/kg, i.p) suppressed the place preference produced by morphine in a dose-dependent manner. These findings provide the first demonstration that ketamine alone produces a place preference using the conditioned-place preference (CPP) paradigm, but that mice treated with ketamine combined with morphine show neither a morphine-nor a ketamine-induced place preference. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalLife Sciences
Volume67
Issue number4
DOIs
Publication statusPublished - Jun 16 2000
Externally publishedYes

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Ketamine
N-Methyl-D-Aspartate Receptors
Morphine
Dizocilpine Maleate
Demonstrations
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Effects of the non-competitive NMDA receptor antagonist ketamine on morphine-induced place preference in mice. / Suzuki, Tsutomu; Kato, Hideaki; Aoki, Takeshi; Makoto, Tsuda; Narita, Minoru; Misawa, Miwa.

In: Life Sciences, Vol. 67, No. 4, 16.06.2000, p. 383-389.

Research output: Contribution to journalArticle

Suzuki, Tsutomu ; Kato, Hideaki ; Aoki, Takeshi ; Makoto, Tsuda ; Narita, Minoru ; Misawa, Miwa. / Effects of the non-competitive NMDA receptor antagonist ketamine on morphine-induced place preference in mice. In: Life Sciences. 2000 ; Vol. 67, No. 4. pp. 383-389.
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