Effects of the non-competitive NMDA receptor antagonist ketamine on morphine-induced place preference in mice

Tsutomu Suzuki, Hideaki Kato, Takeshi Aoki, Makoto Tsuda, Minoru Narita, Miwa Misawa

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46 Citations (Scopus)


The effects of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, on morphine-induced place preference were examined in mice. Morphine (1-5 mg/kg, s.c.)produced a dose-related place preference in mice. Ketamine alone (3, 10 mg/kg, i.p.), like dizocilpine alone (0.2 mg/kg, i.p.), also produced a preference for the drug-associated place. Pretreatment with ketamine (10 mg/kg, i.p.) or dizocilpine (0.1 and 0.2 mg/kg, i.p) suppressed the place preference produced by morphine in a dose-dependent manner. These findings provide the first demonstration that ketamine alone produces a place preference using the conditioned-place preference (CPP) paradigm, but that mice treated with ketamine combined with morphine show neither a morphine-nor a ketamine-induced place preference. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalLife Sciences
Issue number4
Publication statusPublished - Jun 16 2000
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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