TY - JOUR
T1 - Effects of the non-competitive NMDA receptor antagonist ketamine on morphine-induced place preference in mice
AU - Suzuki, Tsutomu
AU - Kato, Hideaki
AU - Aoki, Takeshi
AU - Tsuda, Makoto
AU - Narita, Minoru
AU - Misawa, Miwa
N1 - Funding Information:
This work was supported in part by grants from the Ministry of Health and Welfare, and the Ministry of Education, Science, Sports and Culture of Japan to T. Suzuki. We appreciate technical assistance of Ms. Teruyo Kishino and Mr. Satoru Ozaki. We also thank Ms. Mei Chu for her reading the manuscript.
PY - 2000/6/16
Y1 - 2000/6/16
N2 - The effects of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, on morphine-induced place preference were examined in mice. Morphine (1-5 mg/kg, s.c.)produced a dose-related place preference in mice. Ketamine alone (3, 10 mg/kg, i.p.), like dizocilpine alone (0.2 mg/kg, i.p.), also produced a preference for the drug-associated place. Pretreatment with ketamine (10 mg/kg, i.p.) or dizocilpine (0.1 and 0.2 mg/kg, i.p) suppressed the place preference produced by morphine in a dose-dependent manner. These findings provide the first demonstration that ketamine alone produces a place preference using the conditioned-place preference (CPP) paradigm, but that mice treated with ketamine combined with morphine show neither a morphine-nor a ketamine-induced place preference. (C) 2000 Elsevier Science Inc.
AB - The effects of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, on morphine-induced place preference were examined in mice. Morphine (1-5 mg/kg, s.c.)produced a dose-related place preference in mice. Ketamine alone (3, 10 mg/kg, i.p.), like dizocilpine alone (0.2 mg/kg, i.p.), also produced a preference for the drug-associated place. Pretreatment with ketamine (10 mg/kg, i.p.) or dizocilpine (0.1 and 0.2 mg/kg, i.p) suppressed the place preference produced by morphine in a dose-dependent manner. These findings provide the first demonstration that ketamine alone produces a place preference using the conditioned-place preference (CPP) paradigm, but that mice treated with ketamine combined with morphine show neither a morphine-nor a ketamine-induced place preference. (C) 2000 Elsevier Science Inc.
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U2 - 10.1016/S0024-3205(00)00639-1
DO - 10.1016/S0024-3205(00)00639-1
M3 - Article
C2 - 11003048
AN - SCOPUS:0034674494
VL - 67
SP - 383
EP - 389
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 4
ER -