Abstract
The effects of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, on morphine-induced place preference were examined in mice. Morphine (1-5 mg/kg, s.c.)produced a dose-related place preference in mice. Ketamine alone (3, 10 mg/kg, i.p.), like dizocilpine alone (0.2 mg/kg, i.p.), also produced a preference for the drug-associated place. Pretreatment with ketamine (10 mg/kg, i.p.) or dizocilpine (0.1 and 0.2 mg/kg, i.p) suppressed the place preference produced by morphine in a dose-dependent manner. These findings provide the first demonstration that ketamine alone produces a place preference using the conditioned-place preference (CPP) paradigm, but that mice treated with ketamine combined with morphine show neither a morphine-nor a ketamine-induced place preference. (C) 2000 Elsevier Science Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 383-389 |
| Number of pages | 7 |
| Journal | Life Sciences |
| Volume | 67 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jun 16 2000 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Effects of the non-competitive NMDA receptor antagonist ketamine on morphine-induced place preference in mice. / Suzuki, Tsutomu; Kato, Hideaki; Aoki, Takeshi; Makoto, Tsuda; Narita, Minoru; Misawa, Miwa.
In: Life Sciences, Vol. 67, No. 4, 16.06.2000, p. 383-389.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of the non-competitive NMDA receptor antagonist ketamine on morphine-induced place preference in mice
AU - Suzuki, Tsutomu
AU - Kato, Hideaki
AU - Aoki, Takeshi
AU - Makoto, Tsuda
AU - Narita, Minoru
AU - Misawa, Miwa
PY - 2000/6/16
Y1 - 2000/6/16
N2 - The effects of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, on morphine-induced place preference were examined in mice. Morphine (1-5 mg/kg, s.c.)produced a dose-related place preference in mice. Ketamine alone (3, 10 mg/kg, i.p.), like dizocilpine alone (0.2 mg/kg, i.p.), also produced a preference for the drug-associated place. Pretreatment with ketamine (10 mg/kg, i.p.) or dizocilpine (0.1 and 0.2 mg/kg, i.p) suppressed the place preference produced by morphine in a dose-dependent manner. These findings provide the first demonstration that ketamine alone produces a place preference using the conditioned-place preference (CPP) paradigm, but that mice treated with ketamine combined with morphine show neither a morphine-nor a ketamine-induced place preference. (C) 2000 Elsevier Science Inc.
AB - The effects of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, on morphine-induced place preference were examined in mice. Morphine (1-5 mg/kg, s.c.)produced a dose-related place preference in mice. Ketamine alone (3, 10 mg/kg, i.p.), like dizocilpine alone (0.2 mg/kg, i.p.), also produced a preference for the drug-associated place. Pretreatment with ketamine (10 mg/kg, i.p.) or dizocilpine (0.1 and 0.2 mg/kg, i.p) suppressed the place preference produced by morphine in a dose-dependent manner. These findings provide the first demonstration that ketamine alone produces a place preference using the conditioned-place preference (CPP) paradigm, but that mice treated with ketamine combined with morphine show neither a morphine-nor a ketamine-induced place preference. (C) 2000 Elsevier Science Inc.
UR - http://www.scopus.com/inward/record.url?scp=0034674494&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034674494&partnerID=8YFLogxK
U2 - 10.1016/S0024-3205(00)00639-1
DO - 10.1016/S0024-3205(00)00639-1
M3 - Article
C2 - 11003048
AN - SCOPUS:0034674494
VL - 67
SP - 383
EP - 389
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 4
ER -