Effects of thromboxane A2 antagonist on airway hyperresponsiveness, exhaled nitric oxide, and induced sputum eosinophils in asthmatics

H. Aizawa, H. Inoue, H. Nakano, K. Matsumoto, M. Yoshida, S. Fukuyama, H. Koto, N. Hara

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Abstract

We examined effects of a thromboxane A2 (TXA2) antagonist seratrodast on airway hyperresponsiveness, exhaled nitric oxide (NO), and eosinophils in induced sputum in 14 asthmatics. Subjects were administered 80 mg of seratrodast once a day for 4 weeks. Respiratory conductance (Grs) was measured by the forced oscillation method and airway responsiveness was evaluated as the inhaled dose of methacholine, which induced 35% decrease in Grs. Subjects breathed into a Teflon bag, and NO concentration in the bag was measured by a chemiluminescence analyzer. Induced sputum comprised the entire expectorate produced during a 20 min inhalation of 3% saline, and was analyzed for total and differential cell counts. Airway hyperresponsiveness was significantly decreased by seratrodast. By contrast, no differences in either exhaled NO or percentage of eosinophils in sputum were observed before or after seratrodast. We conclude that seratrodast may attenuate airway hyperresponsiveness, presumably by antagonizing TXA2 released from the inflamed airways.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume59
Issue number3
DOIs
Publication statusPublished - Sep 1998

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All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Cell Biology

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