Effects of transforming growth factor beta 1 on the plasminogen activation system, collagen and integrin synthesis, and proliferation of rabbit mandibular condylar chondrocytes

H. Ishibashi; Y. Nariai; T. Kanno; M. Onimaru; J. Sekine

doi:10.1016/j.ijom.2013.10.010

Effects of transforming growth factor beta 1 on the plasminogen activation system, collagen and integrin synthesis, and proliferation of rabbit mandibular condylar chondrocytes

H. Ishibashi, Y. Nariai, T. Kanno, M. Onimaru, J. Sekine

Pathobiology

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The objective of this study was to identify the mechanism by which mandibular condyle chondrocytes regulate the extracellular matrix. Primary rabbit condylar chondrocytes were isolated, cultured, and treated with transforming growth factor beta 1 (TGF-β1). Cells were then assayed for the following: urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1), collagen types I and II, β1 integrin expression, and proliferative activity. TGF-β1 induced synthesis of collagen type II, αVβ1 integrin, and PAI-1. TGF-β1 induced the growth of chondrocytes and suppressed the synthesis of uPA. Chondrocyte regulation of the extracellular matrix is mediated by TGF-β1. Synthesis of collagen type II, αVβ1 integrin, and PAI-1 is induced, while uPA is suppressed. Also, TGF-β1 induces cellular growth.

Original language	English
Pages (from-to)	470-475
Number of pages	6
Journal	International Journal of Oral and Maxillofacial Surgery
Volume	43
Issue number	4
DOIs	https://doi.org/10.1016/j.ijom.2013.10.010
Publication status	Published - Apr 2014

All Science Journal Classification (ASJC) codes

Surgery
Oral Surgery
Otorhinolaryngology

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Effects of transforming growth factor beta 1 on the plasminogen activation system, collagen and integrin synthesis, and proliferation of rabbit mandibular condylar chondrocytes. / Ishibashi, H.; Nariai, Y.; Kanno, T.; Onimaru, M.; Sekine, J.

In: International Journal of Oral and Maxillofacial Surgery, Vol. 43, No. 4, 04.2014, p. 470-475.

Research output: Contribution to journal › Article › peer-review

Ishibashi, H, Nariai, Y, Kanno, T, Onimaru, M & Sekine, J 2014, 'Effects of transforming growth factor beta 1 on the plasminogen activation system, collagen and integrin synthesis, and proliferation of rabbit mandibular condylar chondrocytes', International Journal of Oral and Maxillofacial Surgery, vol. 43, no. 4, pp. 470-475. https://doi.org/10.1016/j.ijom.2013.10.010

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