Abstract
Background: Although ultrasound (US) is widely used in cardiology, little is known about the effects of US energy on cardiac performance. This study aimed to investigate the mechanical effects of high-intensity continuous US energy (1.0 MHz with 3 different intensities) on cardiac performance. Methods and Results: Either left ventricular (LV) pressure or aortic blood flow (ABF) was evaluated in open-chest guinea pigs (n=30) under surface ECG monitoring. LV systolic pressure and ABF increased significantly (ie, maximum percent increases in these parameters were 2.5%, 3.1% and 7.1% for LV systolic pressure and 9.4%, 4.9% and 8.8% for mean ABF at intensities of 0.06, 0.67 and 2.90 W/cm 2, respectively). LV end-diastolic pressure was reduced significantly by US (5.3±0.9 to 4.8±0.8, 5.5±1.3 to 4.8±1.0 and 5.8±2.0 to 5.0±1.2 mmHg, respectively), indicating positive inotropic and lusitropic effects and resultant ABF augmentation. Local temperature was not significantly changed. ECG showed neither chronotropic action nor arrhythmogenesis. Conclusions: Although the basic mechanisms of these phenomena remain unclear, this pilot study of the short-term effects of US energy on cardiac performance suggests the possibility of physical therapy for heart failure.
| Original language | English |
|---|---|
| Pages (from-to) | 1356-1361 |
| Number of pages | 6 |
| Journal | Circulation Journal |
| Volume | 70 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2 2006 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
Effects of ultrasound energy application on cardiac performance in open-chest guinea pigs - An in vivo pilot study. / Kuma, Fumiaki; Ueda, Norihiro; Ito, Hiroyuki; Maruyama, Toru; Kaji, Yoshikazu; Fujino, Takehiko; Harada, Mine.
In: Circulation Journal, Vol. 70, No. 10, 02.10.2006, p. 1356-1361.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of ultrasound energy application on cardiac performance in open-chest guinea pigs - An in vivo pilot study
AU - Kuma, Fumiaki
AU - Ueda, Norihiro
AU - Ito, Hiroyuki
AU - Maruyama, Toru
AU - Kaji, Yoshikazu
AU - Fujino, Takehiko
AU - Harada, Mine
PY - 2006/10/2
Y1 - 2006/10/2
N2 - Background: Although ultrasound (US) is widely used in cardiology, little is known about the effects of US energy on cardiac performance. This study aimed to investigate the mechanical effects of high-intensity continuous US energy (1.0 MHz with 3 different intensities) on cardiac performance. Methods and Results: Either left ventricular (LV) pressure or aortic blood flow (ABF) was evaluated in open-chest guinea pigs (n=30) under surface ECG monitoring. LV systolic pressure and ABF increased significantly (ie, maximum percent increases in these parameters were 2.5%, 3.1% and 7.1% for LV systolic pressure and 9.4%, 4.9% and 8.8% for mean ABF at intensities of 0.06, 0.67 and 2.90 W/cm 2, respectively). LV end-diastolic pressure was reduced significantly by US (5.3±0.9 to 4.8±0.8, 5.5±1.3 to 4.8±1.0 and 5.8±2.0 to 5.0±1.2 mmHg, respectively), indicating positive inotropic and lusitropic effects and resultant ABF augmentation. Local temperature was not significantly changed. ECG showed neither chronotropic action nor arrhythmogenesis. Conclusions: Although the basic mechanisms of these phenomena remain unclear, this pilot study of the short-term effects of US energy on cardiac performance suggests the possibility of physical therapy for heart failure.
AB - Background: Although ultrasound (US) is widely used in cardiology, little is known about the effects of US energy on cardiac performance. This study aimed to investigate the mechanical effects of high-intensity continuous US energy (1.0 MHz with 3 different intensities) on cardiac performance. Methods and Results: Either left ventricular (LV) pressure or aortic blood flow (ABF) was evaluated in open-chest guinea pigs (n=30) under surface ECG monitoring. LV systolic pressure and ABF increased significantly (ie, maximum percent increases in these parameters were 2.5%, 3.1% and 7.1% for LV systolic pressure and 9.4%, 4.9% and 8.8% for mean ABF at intensities of 0.06, 0.67 and 2.90 W/cm 2, respectively). LV end-diastolic pressure was reduced significantly by US (5.3±0.9 to 4.8±0.8, 5.5±1.3 to 4.8±1.0 and 5.8±2.0 to 5.0±1.2 mmHg, respectively), indicating positive inotropic and lusitropic effects and resultant ABF augmentation. Local temperature was not significantly changed. ECG showed neither chronotropic action nor arrhythmogenesis. Conclusions: Although the basic mechanisms of these phenomena remain unclear, this pilot study of the short-term effects of US energy on cardiac performance suggests the possibility of physical therapy for heart failure.
UR - http://www.scopus.com/inward/record.url?scp=33749003216&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749003216&partnerID=8YFLogxK
U2 - 10.1253/circj.70.1356
DO - 10.1253/circj.70.1356
M3 - Article
C2 - 16998272
AN - SCOPUS:33749003216
VL - 70
SP - 1356
EP - 1361
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 10
ER -