Effects of various ammonium salts, amines, polyamines and α-methylornithine on rRNA synthesis in neurula cells of Xenopus laevis and Xenopus borealis

Koichiro Shiokawa, Yuichi Kawazoe, Kosuke Tashiro, K. Yamana

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Xenopus neurula cells were cultured in a medium that contained ammonium salts, amines, polyamines or α-methylornithine, and their rRNA synthesis was examined. All the ammonium salts and amines, but not polyamines, were strong and selective inhibitors of rRNA synthesis at 1.25-5.0 mM. α-Methylornithine did not inhibit rRNA synthesis, although it inhibited ornithine decarboxylase, an enzyme claimed to be a direct stimulator of rRNA synthesis. During the treatment ammonium ions and monomethylamines were accumulated within the treated cells. However, monomethylamines did not induce the accumulation of ammonium ions, and vice versa. Ammonium salts and amines also selectively inhibited rRNA synthesis in Xenopus borealis neurula cells.

Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalCell Differentiation
Volume18
Issue number2
DOIs
Publication statusPublished - Jan 1 1986
Externally publishedYes

Fingerprint

Xenopus laevis
Polyamines
Xenopus
Ammonium Compounds
Amines
Salts
Ions
Ornithine Decarboxylase
Cultured Cells
Enzymes
methylamine

All Science Journal Classification (ASJC) codes

  • Developmental Biology

Cite this

Effects of various ammonium salts, amines, polyamines and α-methylornithine on rRNA synthesis in neurula cells of Xenopus laevis and Xenopus borealis. / Shiokawa, Koichiro; Kawazoe, Yuichi; Tashiro, Kosuke; Yamana, K.

In: Cell Differentiation, Vol. 18, No. 2, 01.01.1986, p. 101-108.

Research output: Contribution to journalArticle

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