Effects of vasodilation on cardiac output measured by PulseCO™

Koichi Yamashita, Tomoki Nishiyama, Takeshi Yokoyama, Hidehiro Abe, Masanobu Manabe

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27 Citations (Scopus)


Backgrounds: The instability of cardiac output (CO) measured by PulseCO™ (LiDCO Ltd.) during cardiac surgery has been reported. In the present study, we investigated the effects of vasodilation by prostaglandin E1 (PGE1) on the relation between cardiac output measured by PulseCO™ and that by thermodilution. Methods: Twenty patients who underwent off-pump coronary artery bypass grafting (OPCAB) were enrolled in this study. After premedication with oral diazepam 10 mg, anesthesia was induced with midazolam, fentanyl and vecuronium. CO was measured after anesthesia induction, at PGE1 0.01, 0.02 and 0.04 μg/(kg min) and at 15 min after the stop of the infusion. Results: Systemic vascular resistances (SVRs) by PGE1 at 0.02 and 0.04 μg/(kg min) were significantly lower than the control value. The correlation coefficient (R2) between the two techniques at each point, percentage error and limits of agreement (bias ±2SD of bias) were 0.78, 3, 0.05 ± 0.17 at 0.01 μg/(kg min), 0.20, 10, -0.18 ± 0.12 at .02 μg/(kg min), 0.46, 28, -0.50 ± 0.24 at 0.04 μg/(kg min) and 0.97, 1, 0.02 ± 0.27 L/min at 15 min after stop of infusion, respectively. Conclusion: PulseCO™ might underestimate CO compared to that by bolus thermodilution method when simply decreasing the SVR by infusion of PGE1. Therefore, PulseCO™ might be unsuitable in cardiac surgery.

Original languageEnglish
Pages (from-to)335-339
Number of pages5
JournalJournal of Clinical Monitoring and Computing
Issue number6
Publication statusPublished - Dec 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Health Informatics
  • Critical Care and Intensive Care Medicine
  • Anesthesiology and Pain Medicine


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