Abstract
Backgrounds: The instability of cardiac output (CO) measured by PulseCO™ (LiDCO Ltd.) during cardiac surgery has been reported. In the present study, we investigated the effects of vasodilation by prostaglandin E1 (PGE1) on the relation between cardiac output measured by PulseCO™ and that by thermodilution. Methods: Twenty patients who underwent off-pump coronary artery bypass grafting (OPCAB) were enrolled in this study. After premedication with oral diazepam 10 mg, anesthesia was induced with midazolam, fentanyl and vecuronium. CO was measured after anesthesia induction, at PGE1 0.01, 0.02 and 0.04 μg/(kg min) and at 15 min after the stop of the infusion. Results: Systemic vascular resistances (SVRs) by PGE1 at 0.02 and 0.04 μg/(kg min) were significantly lower than the control value. The correlation coefficient (R2) between the two techniques at each point, percentage error and limits of agreement (bias ±2SD of bias) were 0.78, 3, 0.05 ± 0.17 at 0.01 μg/(kg min), 0.20, 10, -0.18 ± 0.12 at .02 μg/(kg min), 0.46, 28, -0.50 ± 0.24 at 0.04 μg/(kg min) and 0.97, 1, 0.02 ± 0.27 L/min at 15 min after stop of infusion, respectively. Conclusion: PulseCO™ might underestimate CO compared to that by bolus thermodilution method when simply decreasing the SVR by infusion of PGE1. Therefore, PulseCO™ might be unsuitable in cardiac surgery.
| Original language | English |
|---|---|
| Pages (from-to) | 335-339 |
| Number of pages | 5 |
| Journal | Journal of Clinical Monitoring and Computing |
| Volume | 21 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 1 2007 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Health Informatics
- Critical Care and Intensive Care Medicine
- Anesthesiology and Pain Medicine
Cite this
Effects of vasodilation on cardiac output measured by PulseCO™. / Yamashita, Koichi; Nishiyama, Tomoki; Yokoyama, Takeshi; Abe, Hidehiro; Manabe, Masanobu.
In: Journal of Clinical Monitoring and Computing, Vol. 21, No. 6, 01.12.2007, p. 335-339.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of vasodilation on cardiac output measured by PulseCO™
AU - Yamashita, Koichi
AU - Nishiyama, Tomoki
AU - Yokoyama, Takeshi
AU - Abe, Hidehiro
AU - Manabe, Masanobu
PY - 2007/12/1
Y1 - 2007/12/1
N2 - Backgrounds: The instability of cardiac output (CO) measured by PulseCO™ (LiDCO Ltd.) during cardiac surgery has been reported. In the present study, we investigated the effects of vasodilation by prostaglandin E1 (PGE1) on the relation between cardiac output measured by PulseCO™ and that by thermodilution. Methods: Twenty patients who underwent off-pump coronary artery bypass grafting (OPCAB) were enrolled in this study. After premedication with oral diazepam 10 mg, anesthesia was induced with midazolam, fentanyl and vecuronium. CO was measured after anesthesia induction, at PGE1 0.01, 0.02 and 0.04 μg/(kg min) and at 15 min after the stop of the infusion. Results: Systemic vascular resistances (SVRs) by PGE1 at 0.02 and 0.04 μg/(kg min) were significantly lower than the control value. The correlation coefficient (R2) between the two techniques at each point, percentage error and limits of agreement (bias ±2SD of bias) were 0.78, 3, 0.05 ± 0.17 at 0.01 μg/(kg min), 0.20, 10, -0.18 ± 0.12 at .02 μg/(kg min), 0.46, 28, -0.50 ± 0.24 at 0.04 μg/(kg min) and 0.97, 1, 0.02 ± 0.27 L/min at 15 min after stop of infusion, respectively. Conclusion: PulseCO™ might underestimate CO compared to that by bolus thermodilution method when simply decreasing the SVR by infusion of PGE1. Therefore, PulseCO™ might be unsuitable in cardiac surgery.
AB - Backgrounds: The instability of cardiac output (CO) measured by PulseCO™ (LiDCO Ltd.) during cardiac surgery has been reported. In the present study, we investigated the effects of vasodilation by prostaglandin E1 (PGE1) on the relation between cardiac output measured by PulseCO™ and that by thermodilution. Methods: Twenty patients who underwent off-pump coronary artery bypass grafting (OPCAB) were enrolled in this study. After premedication with oral diazepam 10 mg, anesthesia was induced with midazolam, fentanyl and vecuronium. CO was measured after anesthesia induction, at PGE1 0.01, 0.02 and 0.04 μg/(kg min) and at 15 min after the stop of the infusion. Results: Systemic vascular resistances (SVRs) by PGE1 at 0.02 and 0.04 μg/(kg min) were significantly lower than the control value. The correlation coefficient (R2) between the two techniques at each point, percentage error and limits of agreement (bias ±2SD of bias) were 0.78, 3, 0.05 ± 0.17 at 0.01 μg/(kg min), 0.20, 10, -0.18 ± 0.12 at .02 μg/(kg min), 0.46, 28, -0.50 ± 0.24 at 0.04 μg/(kg min) and 0.97, 1, 0.02 ± 0.27 L/min at 15 min after stop of infusion, respectively. Conclusion: PulseCO™ might underestimate CO compared to that by bolus thermodilution method when simply decreasing the SVR by infusion of PGE1. Therefore, PulseCO™ might be unsuitable in cardiac surgery.
UR - http://www.scopus.com/inward/record.url?scp=36048965479&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36048965479&partnerID=8YFLogxK
U2 - 10.1007/s10877-007-9093-9
DO - 10.1007/s10877-007-9093-9
M3 - Article
C2 - 17896183
AN - SCOPUS:36048965479
VL - 21
SP - 335
EP - 339
JO - Journal of Clinical Monitoring and Computing
JF - Journal of Clinical Monitoring and Computing
SN - 1387-1307
IS - 6
ER -