Effects of vitamin E administration on platelet function in diabetes mellitus.

M. Kunisaki, F. Umeda, Toyoshi Inoguchi, J. Watanabe, H. Nawata

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    A decrease in the vitamin E content of human diabetic platelets is closely associated with the accelerated platelet aggregation and platelet prostaglandin metabolism seen in patients with diabetes mellitus. We investigated the effect of vitamin E supplementation on these abnormalities of physiological function and prostaglandin metabolism in 14 non-insulin dependent diabetics with proliferative retinopathy. ADP-induced platelet aggregation was inhibited in vitro by the addition of vitamin E in a dose-dependent manner. However, in lower concentrations considered to be physiological doses in vivo, significantly greater inhibition was observed in diabetic platelets than in the control platelets. Next, alpha-tocopheryl nicotinate was administered to diabetics at a daily dose of 600 mg. The platelet vitamin E content was restored to control levels in 13 of the 14 patients after 2-4 weeks of daily administration. The ADP-induced platelet aggregation rate, platelet thromboxane B2 (TXB2, a stable metabolite of TXA2, a vasoconstrictor production, and plasma TXB2 level were low in all 14 diabetics. In contrast, plasma 6-keto-PGF 1 alpha (a stable metabolite of PGI2, a vasodilator) was significantly increased and therefore the 6-keto-PGF 1 alpha/TXB2 ratio in plasma was restored to within normal limits. These results indicate that vitamin E may improve platelet function and prostaglandin metabolism in diabetes mellitus and may be able to provide further beneficial effects in relation to the development of diabetic vascular complications.

    Original languageEnglish
    Pages (from-to)37-42
    Number of pages6
    JournalDiabetes research (Edinburgh, Lothian)
    Volume14
    Issue number1
    Publication statusPublished - Jan 1 1990

    Fingerprint

    Vitamin E
    Diabetes Mellitus
    Blood Platelets
    Platelet Aggregation
    Prostaglandins
    Prostaglandins F
    Adenosine Diphosphate
    Diabetic Angiopathies
    Thromboxane B2
    Vasoconstrictor Agents
    Epoprostenol
    Vasodilator Agents

    All Science Journal Classification (ASJC) codes

    • Endocrinology
    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Kunisaki, M., Umeda, F., Inoguchi, T., Watanabe, J., & Nawata, H. (1990). Effects of vitamin E administration on platelet function in diabetes mellitus. Diabetes research (Edinburgh, Lothian), 14(1), 37-42.

    Effects of vitamin E administration on platelet function in diabetes mellitus. / Kunisaki, M.; Umeda, F.; Inoguchi, Toyoshi; Watanabe, J.; Nawata, H.

    In: Diabetes research (Edinburgh, Lothian), Vol. 14, No. 1, 01.01.1990, p. 37-42.

    Research output: Contribution to journalArticle

    Kunisaki, M, Umeda, F, Inoguchi, T, Watanabe, J & Nawata, H 1990, 'Effects of vitamin E administration on platelet function in diabetes mellitus.', Diabetes research (Edinburgh, Lothian), vol. 14, no. 1, pp. 37-42.
    Kunisaki M, Umeda F, Inoguchi T, Watanabe J, Nawata H. Effects of vitamin E administration on platelet function in diabetes mellitus. Diabetes research (Edinburgh, Lothian). 1990 Jan 1;14(1):37-42.
    Kunisaki, M. ; Umeda, F. ; Inoguchi, Toyoshi ; Watanabe, J. ; Nawata, H. / Effects of vitamin E administration on platelet function in diabetes mellitus. In: Diabetes research (Edinburgh, Lothian). 1990 ; Vol. 14, No. 1. pp. 37-42.
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