Effects of xylitol-containing chewing gum on the oral microbiota

Kenji Takeuchi, Mikari Asakawa, Takafumi Hashiba, Toru Takeshita, Youji Saeki, Yoshihisa Yamashita

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In this interventional study, a randomized controlled trial was used to evaluate the short-term effects of xylitol-containing chewing gum on the salivary microbiota. In total, 70 healthy adult men recruited from the Japan Ground Self Defense Force participated in the study during a 2-day training at Yamaguchi camp, Yamaguchi Prefecture, Japan. The men were randomly divided into two groups: one group chewed two pieces of xylitol-containing chewing gum 7 times/day for 2 days (n = 34) and the other did not (n = 36). Baseline and follow-up stimulated saliva samples were collected and the salivary microbial composition was assessed using the 16S rRNA gene next-generation sequencing analysis. The total salivary bacterial count was quantified using a quantitative real-time PCR system. No statistically significant difference was found between the two groups regarding any parameter analyzed in the baseline samples; however, the follow-up samples of the test group showed significantly lower total salivary bacterial count than those of the control group. Conversely, no significant difference was observed in the overall composition of the salivary microbiota between the baseline and follow-up samples of the two groups. These results indicate that xylitol-containing chewing gum inhibits the increase in total salivary bacteria over a short time during which the salivary microbial composition is not affected.

Original languageEnglish
Pages (from-to)588-594
Number of pages7
JournalJournal of Oral Science
Volume60
Issue number4
DOIs
Publication statusPublished - Dec 1 2018

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Chewing Gum
Xylitol
Microbiota
Bacterial Load
Japan
Computer Systems
rRNA Genes
Saliva
Real-Time Polymerase Chain Reaction
Randomized Controlled Trials
Bacteria
Control Groups

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

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Effects of xylitol-containing chewing gum on the oral microbiota. / Takeuchi, Kenji; Asakawa, Mikari; Hashiba, Takafumi; Takeshita, Toru; Saeki, Youji; Yamashita, Yoshihisa.

In: Journal of Oral Science, Vol. 60, No. 4, 01.12.2018, p. 588-594.

Research output: Contribution to journalArticle

Takeuchi, Kenji ; Asakawa, Mikari ; Hashiba, Takafumi ; Takeshita, Toru ; Saeki, Youji ; Yamashita, Yoshihisa. / Effects of xylitol-containing chewing gum on the oral microbiota. In: Journal of Oral Science. 2018 ; Vol. 60, No. 4. pp. 588-594.
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