@article{6c7b2ba71866495db23b308213987fcd,
title = "Efficacy of a newly developed bioabsorbable pancreatic clip for distal pancreatectomy in swine",
abstract = "Purpose: At present, ≥ 20% of patients experience clinically relevant postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP). Methods: We developed a new bioabsorbable pancreatic clip (BioPaC) made of polycaprolactone that does not crush the pancreatic parenchyma during occlusion of the pancreatic stump. We confirmed the efficacy of this BioPac in a porcine DP model and compared it to a linear stapling device (Reinforce{\textregistered}). Results: Pigs were killed at 1 month after DP. In the BioPaC group, all swine (n = 3) survived well without POPF. In the Reinforce{\textregistered} group (n = 2), one pig died early at postoperative day 7 with Grade C POPF (amylase 43 700 U/l), and the other survived until 1 month at scarification with biochemical leakage of POPF (amylase 3 725 U/l). Pathologically, the main pancreatic duct and pancreatic parenchyma were well closed by BioPaC. Conclusion: The newly developed BioPaC is effective in a porcine DP model.",
author = "Yamashita, {Yo ichi} and Takanobu Yamao and Yosuke Nakao and Tatsunori Miyata and Yasuhiro Ikegami and Soichiro Yamane and Taiga Ito and Taku Furukawa and Jaeyong Cho and Fanqi Wu and Yasumitsu Fujie and Mitsuru Arima and Shinichi Aishima and Hiroyuki Ijima and Hideo Baba",
note = "Funding Information: We have applied for a PCT patent concerning this work as follows: Baba, H., Yamashita, H., and Ijima, H. inventors; Kumamoto University, and Kyushu University, assignees. Organ Resection Stump Fixing Clip. PCT Application No. PCT/JP2020/011641, filed March 17, 2020. This research was supported by AMED under Grant Number JP18lm0203009 and JP20ml0203112, and Grants-in-Aid for Scientific Research (KAKENHI) under Grant Number 21K19534. This work was supported by the Center for Clinical and Translational Research of Kyushu University and the Kumamoto Innovative Department Organization. Funding Information: We have applied for a PCT patent concerning this work as follows: Baba, H., Yamashita, H., and Ijima, H. inventors; Kumamoto University, and Kyushu University, assignees. Organ Resection Stump Fixing Clip. PCT Application No. PCT/JP2020/011641, filed March 17, 2020. This research was supported by AMED under Grant Number JP18lm0203009 and JP20ml0203112, and Grants-in-Aid for Scientific Research (KAKENHI) under Grant Number 21K19534. This work was supported by the Center for Clinical and Translational Research of Kyushu University and the Kumamoto Innovative Department Organization. Publisher Copyright: {\textcopyright} 2021, The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd.",
year = "2022",
month = jul,
doi = "10.1007/s00595-021-02435-x",
language = "English",
volume = "52",
pages = "1109--1114",
journal = "Surgery Today",
issn = "0941-1291",
publisher = "Springer Japan",
number = "7",
}