Efficacy of intravenous administration of atrial natriuretic peptide after cardiac surgery in neonates and infants

E. Murakami, H. Kado, M. Masuda, Yuichi Shiokawa, K. Fukae, Y. Kanegae, H. Iwaki, T. Shirota, H. Yasui

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Intravenous infusion of alpha-human atrial natriuretic polypeptide (hANP) and furosemide was performed in 12 patients (4: TGA, 3: univentricular heart, 3: HLHS, 2: VSD) after cardiopulmonary bypass. Their mean age at the operation was 68 days (6 patients in neonate), the mean body weight was 3.3 kg. All patients were treated with nitroglycerin in dose of 2 micrograms/kg/min and chlorpromazine in dose of 2.8 micrograms/kg/min and catecholamine in mean dose of 6.5 micrograms/kg/min. The criteria of indication for hANP was poor effect of furosemide alone. The hANP was given for 6-144 hours in dose of 0.1-0.2 microgram/kg/min. With the hANP and furosemide infusion, urine volume increased from 85.0 +/- 14.2 ml/kg/day to 107.9 +/- 25.3 ml/kg/day (p < 0.05), whereas the systemic arterial pressure, the central venous pressure and the renal function were unchanged. We conclude that the combination of the hANP and the furosemide is very effective in neonates and infants.

Original languageEnglish
Pages (from-to)822-825
Number of pages4
JournalKyobu geka. The Japanese journal of thoracic surgery
Volume52
Issue number10
Publication statusPublished - Jan 1 1999

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Atrial Natriuretic Factor
Intravenous Administration
Thoracic Surgery
Furosemide
Newborn Infant
Peptides
Central Venous Pressure
Chlorpromazine
Nitroglycerin
Cardiopulmonary Bypass
Intravenous Infusions
Catecholamines
Arterial Pressure
Body Weight
Urine
Kidney

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Murakami, E., Kado, H., Masuda, M., Shiokawa, Y., Fukae, K., Kanegae, Y., ... Yasui, H. (1999). Efficacy of intravenous administration of atrial natriuretic peptide after cardiac surgery in neonates and infants. Kyobu geka. The Japanese journal of thoracic surgery, 52(10), 822-825.

Efficacy of intravenous administration of atrial natriuretic peptide after cardiac surgery in neonates and infants. / Murakami, E.; Kado, H.; Masuda, M.; Shiokawa, Yuichi; Fukae, K.; Kanegae, Y.; Iwaki, H.; Shirota, T.; Yasui, H.

In: Kyobu geka. The Japanese journal of thoracic surgery, Vol. 52, No. 10, 01.01.1999, p. 822-825.

Research output: Contribution to journalArticle

Murakami, E, Kado, H, Masuda, M, Shiokawa, Y, Fukae, K, Kanegae, Y, Iwaki, H, Shirota, T & Yasui, H 1999, 'Efficacy of intravenous administration of atrial natriuretic peptide after cardiac surgery in neonates and infants', Kyobu geka. The Japanese journal of thoracic surgery, vol. 52, no. 10, pp. 822-825.
Murakami, E. ; Kado, H. ; Masuda, M. ; Shiokawa, Yuichi ; Fukae, K. ; Kanegae, Y. ; Iwaki, H. ; Shirota, T. ; Yasui, H. / Efficacy of intravenous administration of atrial natriuretic peptide after cardiac surgery in neonates and infants. In: Kyobu geka. The Japanese journal of thoracic surgery. 1999 ; Vol. 52, No. 10. pp. 822-825.
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