Efficacy of oral pranlukast hydrate, a leukotriene receptor antagonist, in the treatment of postherpetic neuralgia

Akifumi Kanai, Sayano Mori, Satoru Osawa, Asaha Suzuki, Sumio Hoka

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2 Citations (Scopus)


The purpose of this study is to investigate the analgesic effect of pranlukast hydrate (PH), a leukotriene receptor antagonist, in patients with postherpetic neuralgia (PHN). Twenty patients with PHN whose pain reached a plateau after 3 or more months received oral administration of PH at doses of 450 mg/day for 1 month. Visual analogue scales of rest pain, tactile allodynia, and paroxysmal pain were significantly reduced at 1 week, 2 weeks, and 1 month after the beginning of oral administration. The analgesic effect was better in patients suffering from PHN for 1 year or more than in the others. This suggests that leukotrienes may play a role in PHN.

Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalPain Clinic
Issue number4
Publication statusPublished - Dec 1 2004


All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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