Abstract
In this study, the efficacy of percutaneous transluminal angioplasty (PTA) and intra-arterial infusion of fasudil hydrochloride (FH) on cerebral vasospasm after subarachnoid hemorrhage were reviewed. Twenty-two arterial territories in 15 patients were treated according to the following strategy. Vasospasm located on the proximal intracranial vessels (ICA and M1) was treated with PTA and intra-arterial infusion of FH was selected for vasospasm at more distal locations. Angiographic improvement of vasospasm was demonstrated in 19 territories (86%) and 9 of 11 symptomatic patients (82%) showed neurological improvement after the procedure. Angiographic vasoconstriction recurred in 7 territories (43%), and neurological deficits recurred in 3 patients (33%). Recurrence of vasoconstriction was seen only after intra-arterial infusion of FH. After treating the 22 vascular territories, 16 (73%) were prevented from large ischemic change on post-procedural computed tomographies. There were no episodes of systemic hypotension and no severe adverse effects were encountered. We concluded that the combined use of PTA and intra-arterial infusion of FH was useful for cerebral vasospasm following subarachnoid hemorrhage.
| Original language | English |
|---|---|
| Pages (from-to) | 672-679 |
| Number of pages | 8 |
| Journal | Japanese Journal of Neurosurgery |
| Volume | 11 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 1 2002 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Surgery
- Clinical Neurology
Cite this
Efficacy of percutaneous transluminal angioplasty and intra-arterial infusion of fasudil hydrochloride on cerebral vasospasm following subarachnoid hemorrhage. / Soeda, Akio; Murao, Kenichi; Iihara, Koji; Higashi, Toshio; Kogure, Shuji; Takahashi, Jun C.; Hayashi, Katsuhiko; Ohta, Hajime; Nagamine, Tomoaki; Ishibashi, Toshihiro; Anei, Ryogo; Taniguchi, Ayumi; Fukuda, Hitoshi; Fukui, Naoki; Nagata, Izumi.
In: Japanese Journal of Neurosurgery, Vol. 11, No. 10, 01.10.2002, p. 672-679.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Efficacy of percutaneous transluminal angioplasty and intra-arterial infusion of fasudil hydrochloride on cerebral vasospasm following subarachnoid hemorrhage
AU - Soeda, Akio
AU - Murao, Kenichi
AU - Iihara, Koji
AU - Higashi, Toshio
AU - Kogure, Shuji
AU - Takahashi, Jun C.
AU - Hayashi, Katsuhiko
AU - Ohta, Hajime
AU - Nagamine, Tomoaki
AU - Ishibashi, Toshihiro
AU - Anei, Ryogo
AU - Taniguchi, Ayumi
AU - Fukuda, Hitoshi
AU - Fukui, Naoki
AU - Nagata, Izumi
PY - 2002/10/1
Y1 - 2002/10/1
N2 - In this study, the efficacy of percutaneous transluminal angioplasty (PTA) and intra-arterial infusion of fasudil hydrochloride (FH) on cerebral vasospasm after subarachnoid hemorrhage were reviewed. Twenty-two arterial territories in 15 patients were treated according to the following strategy. Vasospasm located on the proximal intracranial vessels (ICA and M1) was treated with PTA and intra-arterial infusion of FH was selected for vasospasm at more distal locations. Angiographic improvement of vasospasm was demonstrated in 19 territories (86%) and 9 of 11 symptomatic patients (82%) showed neurological improvement after the procedure. Angiographic vasoconstriction recurred in 7 territories (43%), and neurological deficits recurred in 3 patients (33%). Recurrence of vasoconstriction was seen only after intra-arterial infusion of FH. After treating the 22 vascular territories, 16 (73%) were prevented from large ischemic change on post-procedural computed tomographies. There were no episodes of systemic hypotension and no severe adverse effects were encountered. We concluded that the combined use of PTA and intra-arterial infusion of FH was useful for cerebral vasospasm following subarachnoid hemorrhage.
AB - In this study, the efficacy of percutaneous transluminal angioplasty (PTA) and intra-arterial infusion of fasudil hydrochloride (FH) on cerebral vasospasm after subarachnoid hemorrhage were reviewed. Twenty-two arterial territories in 15 patients were treated according to the following strategy. Vasospasm located on the proximal intracranial vessels (ICA and M1) was treated with PTA and intra-arterial infusion of FH was selected for vasospasm at more distal locations. Angiographic improvement of vasospasm was demonstrated in 19 territories (86%) and 9 of 11 symptomatic patients (82%) showed neurological improvement after the procedure. Angiographic vasoconstriction recurred in 7 territories (43%), and neurological deficits recurred in 3 patients (33%). Recurrence of vasoconstriction was seen only after intra-arterial infusion of FH. After treating the 22 vascular territories, 16 (73%) were prevented from large ischemic change on post-procedural computed tomographies. There were no episodes of systemic hypotension and no severe adverse effects were encountered. We concluded that the combined use of PTA and intra-arterial infusion of FH was useful for cerebral vasospasm following subarachnoid hemorrhage.
UR - http://www.scopus.com/inward/record.url?scp=0036792038&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036792038&partnerID=8YFLogxK
U2 - 10.7887/jcns.11.672
DO - 10.7887/jcns.11.672
M3 - Article
AN - SCOPUS:0036792038
VL - 11
SP - 672
EP - 679
JO - Japanese Journal of Neurosurgery
JF - Japanese Journal of Neurosurgery
SN - 0917-950X
IS - 10
ER -