Efficacy of postoperative anticoagulation therapy with enoxaparin for portal vein thrombosis after hepatic resection in patients with liver cancer

Yo Ichi Yamashita, Yuki Bekki, Daisuke Imai, Toru Ikegami, Tomoharu Yoshizumi, Tetsuo Ikeda, Hirofumi Kawanaka, Akihiro Nishie, Ken Shirabe, Yoshihiko Maehara

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Backgrounds: Enoxaparin, low-molecular-weight heparin, has become a routine thromboprophylaxis in general surgery. Study design: A retrospective cohort study was performed in 281 patients who underwent hepatic resections for liver cancers from 2011 to 2013. These patients were divided into two groups; an enoxaparin (-) group (n = 228) and an enoxaparin (+) group (n = 53). Short-term surgical results including venous thromboembolism (VTE) and portal vein thrombosis (PVT) were compared. Results: In the enoxaparin (+) group, the patients' age (65 vs. 69 years; p = 0.01) and BMI (22.9 vs. 24.4; p < 0.01) were significantly higher. According to the symptomatic VTE, symptomatic pulmonary embolism occurred in one patient (0.4%) in the enoxaparin (-) group, but the complication rate was not significantly different (p = 0.63). The complication rate of PVT was significantly lower in the enoxaparin (+) group (10 vs. 2%; p = 0.04). The independent risk factors for PVT were an operation time ≥ 300 minutes (Odds ratio 6.66) and non-treatment with enoxaparin (Odds ratio 2.49). Conclusions: Postoperative anticoagulant therapy with enoxaparin could prevent PVT in patients who underwent hepatic resection for liver cancers.

Original languageEnglish
Pages (from-to)826-831
Number of pages6
JournalThrombosis Research
Volume134
Issue number4
DOIs
Publication statusPublished - Oct 1 2014

All Science Journal Classification (ASJC) codes

  • Hematology

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