Efficacy of second-look laparotomy for patients with epithelial ovarian carcinoma

T. Kamura, N. Tsukamoto, T. Saito, T. Kaku, T. Matsuyama, H. Nakano

Research output: Contribution to journalArticle

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Abstract

Second-look laparotomies (SLL) were performed on 42 patients with ovarian carcinoma. Ten (24%) had residual disease. Serum CA 125 values before SLL predicted the presence of residual tumors, but its relatively high false negative rate made it unable to take place of SLL. Positive peritoneal cytology at initial surgery significantly influenced SLL results in patients with early disease. Residual pelvic lesions at initial surgery seemed to resist subsequent chemotherapy. Salvage therapy with external pelvic irradiation was effective on lesions confined to the pelvis without serious toxicity. Patients with advanced disease, undergoing SLL achieved better survival than without SLL. This study shows SLL is still the most accurate procedure in assessing the efficacy of treatment, and useful in selecting second-line therapy.

Original languageEnglish
Pages (from-to)141-147
Number of pages7
JournalInternational Journal of Gynecology and Obstetrics
Volume33
Issue number2
DOIs
Publication statusPublished - Oct 1990

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Laparotomy
Carcinoma
Salvage Therapy
Residual Neoplasm
Pelvis
Cell Biology
Drug Therapy
Survival
Serum

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Efficacy of second-look laparotomy for patients with epithelial ovarian carcinoma. / Kamura, T.; Tsukamoto, N.; Saito, T.; Kaku, T.; Matsuyama, T.; Nakano, H.

In: International Journal of Gynecology and Obstetrics, Vol. 33, No. 2, 10.1990, p. 141-147.

Research output: Contribution to journalArticle

Kamura, T. ; Tsukamoto, N. ; Saito, T. ; Kaku, T. ; Matsuyama, T. ; Nakano, H. / Efficacy of second-look laparotomy for patients with epithelial ovarian carcinoma. In: International Journal of Gynecology and Obstetrics. 1990 ; Vol. 33, No. 2. pp. 141-147.
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