Efficacy of splenectomy in preventing anemia in patients with recurrent hepatitis C following liver transplantation is not dependent on inosine triphosphate pyrophosphatase genotype

Takashi Motomura, Erina Koga, Akinobu Taketomi, Takasuke Fukuhara, Yohei Mano, Jun Muto, Hideyuki Konishi, Takeo Toshima, Hideaki Uchiyama, Tomoharu Yoshizumi, Ken Shirabe, Yoshihiko Maehara

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Abstract

Aim: A genetic polymorphism of inosine triphosphate pyrophosphatase (ITPA) has been associated with pegylated-interferon/ribavirin (PEG-IFN/RBV)-induced anemia in chronic hepatitis C patients. However, correlation of the genetic variant with anemia following liver transplantation has not been determined. Methods: Sixty-three hepatitis C virus (HCV)-positive patients who underwent liver transplantation and PEG-IFN/RBV therapy were enrolled. The rs1127354 was determined for each individual. Results: There was no relationship with anemia or RBV dosage in patients carrying the CC allele (CC group, n=43) and those carrying the CA allele (CA group, n=20). The incidence of hemoglobin (Hb) decline >3g/dL (CC: 4.7%, CA: 0%) was relatively low, whereas the incidence of Hb levels <10g/dL (CC: 18.6%, CA: 30.0%) was high. Univariate analysis revealed that splenectomy inversely correlated with Hb levels <10g/dL at 4weeks (P=0.04). Among the 22 patients who did not undergo splenectomy, the incidence of Hb levels <10g/dL tended to be lower in the seven patients carrying the CA allele (28.6%) than in the 15 patients with the CC allele (60.0%). Conclusion: The ITPA genetic polymorphism does not correlate with post-transplant PEG-IFN/RBV-induced anemia. Splenectomy is useful in preventing anemia regardless of the ITPA genotype.

Original languageEnglish
Pages (from-to)288-295
Number of pages8
JournalHepatology Research
Volume42
Issue number3
DOIs
Publication statusPublished - Mar 1 2012

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Pyrophosphatases
Inosine Triphosphate
Splenectomy
Hepatitis C
Liver Transplantation
Anemia
Genotype
Ribavirin
Hemoglobins
Alleles
Interferons
Genetic Polymorphisms
Incidence
Chronic Hepatitis C
Hepacivirus
Transplants

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Infectious Diseases

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Efficacy of splenectomy in preventing anemia in patients with recurrent hepatitis C following liver transplantation is not dependent on inosine triphosphate pyrophosphatase genotype. / Motomura, Takashi; Koga, Erina; Taketomi, Akinobu; Fukuhara, Takasuke; Mano, Yohei; Muto, Jun; Konishi, Hideyuki; Toshima, Takeo; Uchiyama, Hideaki; Yoshizumi, Tomoharu; Shirabe, Ken; Maehara, Yoshihiko.

In: Hepatology Research, Vol. 42, No. 3, 01.03.2012, p. 288-295.

Research output: Contribution to journalArticle

Motomura, Takashi ; Koga, Erina ; Taketomi, Akinobu ; Fukuhara, Takasuke ; Mano, Yohei ; Muto, Jun ; Konishi, Hideyuki ; Toshima, Takeo ; Uchiyama, Hideaki ; Yoshizumi, Tomoharu ; Shirabe, Ken ; Maehara, Yoshihiko. / Efficacy of splenectomy in preventing anemia in patients with recurrent hepatitis C following liver transplantation is not dependent on inosine triphosphate pyrophosphatase genotype. In: Hepatology Research. 2012 ; Vol. 42, No. 3. pp. 288-295.
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abstract = "Aim: A genetic polymorphism of inosine triphosphate pyrophosphatase (ITPA) has been associated with pegylated-interferon/ribavirin (PEG-IFN/RBV)-induced anemia in chronic hepatitis C patients. However, correlation of the genetic variant with anemia following liver transplantation has not been determined. Methods: Sixty-three hepatitis C virus (HCV)-positive patients who underwent liver transplantation and PEG-IFN/RBV therapy were enrolled. The rs1127354 was determined for each individual. Results: There was no relationship with anemia or RBV dosage in patients carrying the CC allele (CC group, n=43) and those carrying the CA allele (CA group, n=20). The incidence of hemoglobin (Hb) decline >3g/dL (CC: 4.7{\%}, CA: 0{\%}) was relatively low, whereas the incidence of Hb levels <10g/dL (CC: 18.6{\%}, CA: 30.0{\%}) was high. Univariate analysis revealed that splenectomy inversely correlated with Hb levels <10g/dL at 4weeks (P=0.04). Among the 22 patients who did not undergo splenectomy, the incidence of Hb levels <10g/dL tended to be lower in the seven patients carrying the CA allele (28.6{\%}) than in the 15 patients with the CC allele (60.0{\%}). Conclusion: The ITPA genetic polymorphism does not correlate with post-transplant PEG-IFN/RBV-induced anemia. Splenectomy is useful in preventing anemia regardless of the ITPA genotype.",
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AU - Motomura, Takashi

AU - Koga, Erina

AU - Taketomi, Akinobu

AU - Fukuhara, Takasuke

AU - Mano, Yohei

AU - Muto, Jun

AU - Konishi, Hideyuki

AU - Toshima, Takeo

AU - Uchiyama, Hideaki

AU - Yoshizumi, Tomoharu

AU - Shirabe, Ken

AU - Maehara, Yoshihiko

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N2 - Aim: A genetic polymorphism of inosine triphosphate pyrophosphatase (ITPA) has been associated with pegylated-interferon/ribavirin (PEG-IFN/RBV)-induced anemia in chronic hepatitis C patients. However, correlation of the genetic variant with anemia following liver transplantation has not been determined. Methods: Sixty-three hepatitis C virus (HCV)-positive patients who underwent liver transplantation and PEG-IFN/RBV therapy were enrolled. The rs1127354 was determined for each individual. Results: There was no relationship with anemia or RBV dosage in patients carrying the CC allele (CC group, n=43) and those carrying the CA allele (CA group, n=20). The incidence of hemoglobin (Hb) decline >3g/dL (CC: 4.7%, CA: 0%) was relatively low, whereas the incidence of Hb levels <10g/dL (CC: 18.6%, CA: 30.0%) was high. Univariate analysis revealed that splenectomy inversely correlated with Hb levels <10g/dL at 4weeks (P=0.04). Among the 22 patients who did not undergo splenectomy, the incidence of Hb levels <10g/dL tended to be lower in the seven patients carrying the CA allele (28.6%) than in the 15 patients with the CC allele (60.0%). Conclusion: The ITPA genetic polymorphism does not correlate with post-transplant PEG-IFN/RBV-induced anemia. Splenectomy is useful in preventing anemia regardless of the ITPA genotype.

AB - Aim: A genetic polymorphism of inosine triphosphate pyrophosphatase (ITPA) has been associated with pegylated-interferon/ribavirin (PEG-IFN/RBV)-induced anemia in chronic hepatitis C patients. However, correlation of the genetic variant with anemia following liver transplantation has not been determined. Methods: Sixty-three hepatitis C virus (HCV)-positive patients who underwent liver transplantation and PEG-IFN/RBV therapy were enrolled. The rs1127354 was determined for each individual. Results: There was no relationship with anemia or RBV dosage in patients carrying the CC allele (CC group, n=43) and those carrying the CA allele (CA group, n=20). The incidence of hemoglobin (Hb) decline >3g/dL (CC: 4.7%, CA: 0%) was relatively low, whereas the incidence of Hb levels <10g/dL (CC: 18.6%, CA: 30.0%) was high. Univariate analysis revealed that splenectomy inversely correlated with Hb levels <10g/dL at 4weeks (P=0.04). Among the 22 patients who did not undergo splenectomy, the incidence of Hb levels <10g/dL tended to be lower in the seven patients carrying the CA allele (28.6%) than in the 15 patients with the CC allele (60.0%). Conclusion: The ITPA genetic polymorphism does not correlate with post-transplant PEG-IFN/RBV-induced anemia. Splenectomy is useful in preventing anemia regardless of the ITPA genotype.

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