Abstract
Aim: A genetic polymorphism of inosine triphosphate pyrophosphatase (ITPA) has been associated with pegylated-interferon/ribavirin (PEG-IFN/RBV)-induced anemia in chronic hepatitis C patients. However, correlation of the genetic variant with anemia following liver transplantation has not been determined. Methods: Sixty-three hepatitis C virus (HCV)-positive patients who underwent liver transplantation and PEG-IFN/RBV therapy were enrolled. The rs1127354 was determined for each individual. Results: There was no relationship with anemia or RBV dosage in patients carrying the CC allele (CC group, n=43) and those carrying the CA allele (CA group, n=20). The incidence of hemoglobin (Hb) decline >3g/dL (CC: 4.7%, CA: 0%) was relatively low, whereas the incidence of Hb levels <10g/dL (CC: 18.6%, CA: 30.0%) was high. Univariate analysis revealed that splenectomy inversely correlated with Hb levels <10g/dL at 4weeks (P=0.04). Among the 22 patients who did not undergo splenectomy, the incidence of Hb levels <10g/dL tended to be lower in the seven patients carrying the CA allele (28.6%) than in the 15 patients with the CC allele (60.0%). Conclusion: The ITPA genetic polymorphism does not correlate with post-transplant PEG-IFN/RBV-induced anemia. Splenectomy is useful in preventing anemia regardless of the ITPA genotype.
| Original language | English |
|---|---|
| Pages (from-to) | 288-295 |
| Number of pages | 8 |
| Journal | Hepatology Research |
| Volume | 42 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 1 2012 |
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All Science Journal Classification (ASJC) codes
- Hepatology
- Infectious Diseases
Cite this
Efficacy of splenectomy in preventing anemia in patients with recurrent hepatitis C following liver transplantation is not dependent on inosine triphosphate pyrophosphatase genotype. / Motomura, Takashi; Koga, Erina; Taketomi, Akinobu; Fukuhara, Takasuke; Mano, Yohei; Muto, Jun; Konishi, Hideyuki; Toshima, Takeo; Uchiyama, Hideaki; Yoshizumi, Tomoharu; Shirabe, Ken; Maehara, Yoshihiko.
In: Hepatology Research, Vol. 42, No. 3, 01.03.2012, p. 288-295.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Efficacy of splenectomy in preventing anemia in patients with recurrent hepatitis C following liver transplantation is not dependent on inosine triphosphate pyrophosphatase genotype
AU - Motomura, Takashi
AU - Koga, Erina
AU - Taketomi, Akinobu
AU - Fukuhara, Takasuke
AU - Mano, Yohei
AU - Muto, Jun
AU - Konishi, Hideyuki
AU - Toshima, Takeo
AU - Uchiyama, Hideaki
AU - Yoshizumi, Tomoharu
AU - Shirabe, Ken
AU - Maehara, Yoshihiko
PY - 2012/3/1
Y1 - 2012/3/1
N2 - Aim: A genetic polymorphism of inosine triphosphate pyrophosphatase (ITPA) has been associated with pegylated-interferon/ribavirin (PEG-IFN/RBV)-induced anemia in chronic hepatitis C patients. However, correlation of the genetic variant with anemia following liver transplantation has not been determined. Methods: Sixty-three hepatitis C virus (HCV)-positive patients who underwent liver transplantation and PEG-IFN/RBV therapy were enrolled. The rs1127354 was determined for each individual. Results: There was no relationship with anemia or RBV dosage in patients carrying the CC allele (CC group, n=43) and those carrying the CA allele (CA group, n=20). The incidence of hemoglobin (Hb) decline >3g/dL (CC: 4.7%, CA: 0%) was relatively low, whereas the incidence of Hb levels <10g/dL (CC: 18.6%, CA: 30.0%) was high. Univariate analysis revealed that splenectomy inversely correlated with Hb levels <10g/dL at 4weeks (P=0.04). Among the 22 patients who did not undergo splenectomy, the incidence of Hb levels <10g/dL tended to be lower in the seven patients carrying the CA allele (28.6%) than in the 15 patients with the CC allele (60.0%). Conclusion: The ITPA genetic polymorphism does not correlate with post-transplant PEG-IFN/RBV-induced anemia. Splenectomy is useful in preventing anemia regardless of the ITPA genotype.
AB - Aim: A genetic polymorphism of inosine triphosphate pyrophosphatase (ITPA) has been associated with pegylated-interferon/ribavirin (PEG-IFN/RBV)-induced anemia in chronic hepatitis C patients. However, correlation of the genetic variant with anemia following liver transplantation has not been determined. Methods: Sixty-three hepatitis C virus (HCV)-positive patients who underwent liver transplantation and PEG-IFN/RBV therapy were enrolled. The rs1127354 was determined for each individual. Results: There was no relationship with anemia or RBV dosage in patients carrying the CC allele (CC group, n=43) and those carrying the CA allele (CA group, n=20). The incidence of hemoglobin (Hb) decline >3g/dL (CC: 4.7%, CA: 0%) was relatively low, whereas the incidence of Hb levels <10g/dL (CC: 18.6%, CA: 30.0%) was high. Univariate analysis revealed that splenectomy inversely correlated with Hb levels <10g/dL at 4weeks (P=0.04). Among the 22 patients who did not undergo splenectomy, the incidence of Hb levels <10g/dL tended to be lower in the seven patients carrying the CA allele (28.6%) than in the 15 patients with the CC allele (60.0%). Conclusion: The ITPA genetic polymorphism does not correlate with post-transplant PEG-IFN/RBV-induced anemia. Splenectomy is useful in preventing anemia regardless of the ITPA genotype.
UR - http://www.scopus.com/inward/record.url?scp=84857517874&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857517874&partnerID=8YFLogxK
U2 - 10.1111/j.1872-034X.2011.00927.x
DO - 10.1111/j.1872-034X.2011.00927.x
M3 - Article
C2 - 22181672
AN - SCOPUS:84857517874
VL - 42
SP - 288
EP - 295
JO - Hepatology Research
JF - Hepatology Research
SN - 1386-6346
IS - 3
ER -