Efficient covalent capture of 8-nitroguanosine via a multiple hydrogen-bonded complex

Yasufumi Fuchi, Shigeki Sasaki

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A novel 1,3-diazaphenoxazine nucleoside derivative (nitroG-Grasp) bearing a thiol group with a urea linker forms multiple hydrogen-bonded complexes with 8-nitroguanosine and efficiently displaces the nitro group; thus, it is the first molecule that can covalently capture 8-nitroguanosine.

Original languageEnglish
Pages (from-to)1760-1763
Number of pages4
JournalOrganic Letters
Volume16
Issue number6
DOIs
Publication statusPublished - Mar 21 2014

Fingerprint

Hydrogen
Bearings (structural)
nucleosides
Hand Strength
hydrogen
ureas
Nucleosides
Sulfhydryl Compounds
thiols
Urea
Derivatives
Molecules
molecules
8-nitroguanosine
1,3-diazaphenoxazine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Efficient covalent capture of 8-nitroguanosine via a multiple hydrogen-bonded complex. / Fuchi, Yasufumi; Sasaki, Shigeki.

In: Organic Letters, Vol. 16, No. 6, 21.03.2014, p. 1760-1763.

Research output: Contribution to journalArticle

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