Efficient design for stimuli-responsive polymers with quantitative acid-degradability: Specifically designed alternating controlled cationic copolymerization and facile complete degradation

Sadahito Aoshima, Yukari Oda, Suzuka Matsumoto, Yu Shinke, Arihiro Kanazawa, Shokyoku Kanaoka

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Specifically designed alternating cationic copolymerization produced well-defined thermo- or pH-responsive polymers with complete acid-degradability. For example, a thermosensitive alternating copolymer with acid-labile acetal linkages in the main chain was obtained from the controlled cationic copolymerization of p-methoxybenzaldehyde (pMeOBzA) and a vinyl ether (VE) with an oxyethylenic side chain. The resulting copolymer exhibited a sharp thermosensitive phase transition in water. The same strategy but using different VEs with esters and benzaldehyde (BzA) yielded pH-responsive copolymers with nearly alternating sequences and narrow molecular weight distributions (MWDs). The alternately arranged acetal bonds in the copolymers allowed complete facile and rapid degradation under acidic conditions, which selectively produced low-molecular-weight compounds (MW ∼ 1-2 × 102).

Original languageEnglish
Pages (from-to)80-85
Number of pages6
JournalACS Macro Letters
Volume3
Issue number1
DOIs
Publication statusPublished - Jan 21 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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