Efficient synthesis of bongkrekic acid. Three-component convergent strategy

Yukiko Sato; Yoshifumi Aso; Mitsuru Shindo

doi:10.1016/j.tetlet.2009.04.129

Efficient synthesis of bongkrekic acid. Three-component convergent strategy

Yukiko Sato, Yoshifumi Aso, Mitsuru Shindo

Department of Fundamental Organic Chemistry

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

An efficient total synthesis of the apoptosis inhibitor bongkrekic acid was accomplished using a three-component convergent strategy involving a Kocienski-Julia olefination and a Suzuki-Miyaura coupling, in which the longest linear sequence was 18 steps and proceeded in 6.4% overall yield. The torquoselective olefination also contributed to the shortening of the synthesis.

Original language	English
Pages (from-to)	4164-4166
Number of pages	3
Journal	Tetrahedron Letters
Volume	50
Issue number	28
DOIs	https://doi.org/10.1016/j.tetlet.2009.04.129
Publication status	Published - Jul 15 2009

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All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

Sato, Y., Aso, Y., & Shindo, M. (2009). Efficient synthesis of bongkrekic acid. Three-component convergent strategy. Tetrahedron Letters, 50(28), 4164-4166. https://doi.org/10.1016/j.tetlet.2009.04.129

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10.1016/j.tetlet.2009.04.129