Efficient synthesis of bongkrekic acid. Three-component convergent strategy

Yukiko Sato, Yoshifumi Aso, Mitsuru Shindo

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Abstract

An efficient total synthesis of the apoptosis inhibitor bongkrekic acid was accomplished using a three-component convergent strategy involving a Kocienski-Julia olefination and a Suzuki-Miyaura coupling, in which the longest linear sequence was 18 steps and proceeded in 6.4% overall yield. The torquoselective olefination also contributed to the shortening of the synthesis.

Original languageEnglish
Pages (from-to)4164-4166
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number28
DOIs
Publication statusPublished - Jul 15 2009

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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