Efficient synthesis of bongkrekic acid. Three-component convergent strategy

Yukiko Sato, Yoshifumi Aso, Mitsuru Shindo

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

An efficient total synthesis of the apoptosis inhibitor bongkrekic acid was accomplished using a three-component convergent strategy involving a Kocienski-Julia olefination and a Suzuki-Miyaura coupling, in which the longest linear sequence was 18 steps and proceeded in 6.4% overall yield. The torquoselective olefination also contributed to the shortening of the synthesis.

Original languageEnglish
Pages (from-to)4164-4166
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number28
DOIs
Publication statusPublished - Jul 15 2009

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Bongkrekic Acid
Apoptosis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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Efficient synthesis of bongkrekic acid. Three-component convergent strategy. / Sato, Yukiko; Aso, Yoshifumi; Shindo, Mitsuru.

In: Tetrahedron Letters, Vol. 50, No. 28, 15.07.2009, p. 4164-4166.

Research output: Contribution to journal › Article

Sato, Y, Aso, Y & Shindo, M 2009, 'Efficient synthesis of bongkrekic acid. Three-component convergent strategy', Tetrahedron Letters, vol. 50, no. 28, pp. 4164-4166. https://doi.org/10.1016/j.tetlet.2009.04.129
Sato Y, Aso Y, Shindo M. Efficient synthesis of bongkrekic acid. Three-component convergent strategy. Tetrahedron Letters. 2009 Jul 15;50(28):4164-4166. https://doi.org/10.1016/j.tetlet.2009.04.129
Sato, Yukiko ; Aso, Yoshifumi ; Shindo, Mitsuru. / Efficient synthesis of bongkrekic acid. Three-component convergent strategy. In: Tetrahedron Letters. 2009 ; Vol. 50, No. 28. pp. 4164-4166.
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