An efficient total synthesis of the apoptosis inhibitor bongkrekic acid was accomplished using a three-component convergent strategy involving a Kocienski-Julia olefination and a Suzuki-Miyaura coupling, in which the longest linear sequence was 18 steps and proceeded in 6.4% overall yield. The torquoselective olefination also contributed to the shortening of the synthesis.
|Number of pages||3|
|Publication status||Published - Jul 15 2009|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry