Efficient Synthesis of Chiral α- and β-Hydroxy Amides: Application to the Synthesis of (R)-Fluoxetine

Hiroyuki Kakei, Tetsuhiro Nemoto, Takashi Ohshima, Masakatsu Shibasaki

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Four flavors for epoxide openings: The regioselective openings of epoxy amides obtained by asymmetric epoxidation yields all types of aryl- and alkyl-substituted hydroxy amides sometimes counter to the reactivity of the α- and β-positions.

Original languageEnglish
Pages (from-to)317-320
Number of pages4
JournalAngewandte Chemie - International Edition
Volume43
Issue number3
DOIs
Publication statusPublished - Jan 5 2004

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Fluoxetine
Amides
Epoxidation
Flavors
Epoxy Compounds

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Efficient Synthesis of Chiral α- and β-Hydroxy Amides : Application to the Synthesis of (R)-Fluoxetine. / Kakei, Hiroyuki; Nemoto, Tetsuhiro; Ohshima, Takashi; Shibasaki, Masakatsu.

In: Angewandte Chemie - International Edition, Vol. 43, No. 3, 05.01.2004, p. 317-320.

Research output: Contribution to journalArticle

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