Efficient Synthesis of Chiral α- and β-Hydroxy Amides: Application to the Synthesis of (R)-Fluoxetine

Hiroyuki Kakei, Tetsuhiro Nemoto, Takashi Ohshima, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)

Abstract

Four flavors for epoxide openings: The regioselective openings of epoxy amides obtained by asymmetric epoxidation yields all types of aryl- and alkyl-substituted hydroxy amides sometimes counter to the reactivity of the α- and β-positions.

Original languageEnglish
Pages (from-to)317-320
Number of pages4
JournalAngewandte Chemie - International Edition
Volume43
Issue number3
DOIs
Publication statusPublished - Jan 5 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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