Abstract
A novel method for the highly selective synthesis of dissymmetric S,O-malonates starting from symmetric diphenyl dithiomalonates under neutral conditions is described. The key step is the thermal formation of an acylketene, the stability of which would contribute to the selectivity. The synthetic utility of the dissymmetric S,O-malonates is also shown.
| Original language | English |
|---|---|
| Pages (from-to) | 4406-4409 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 13 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - Aug 19 2011 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
Cite this
Efficient synthesis of dissymmetric malonic acid S, O -esters via monoalcoholysis of symmetric dithiomalonates under neutral conditions. / Matsuo, Kazumasa; Shindo, Mitsuru.
In: Organic Letters, Vol. 13, No. 16, 19.08.2011, p. 4406-4409.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficient synthesis of dissymmetric malonic acid S, O -esters via monoalcoholysis of symmetric dithiomalonates under neutral conditions
AU - Matsuo, Kazumasa
AU - Shindo, Mitsuru
PY - 2011/8/19
Y1 - 2011/8/19
N2 - A novel method for the highly selective synthesis of dissymmetric S,O-malonates starting from symmetric diphenyl dithiomalonates under neutral conditions is described. The key step is the thermal formation of an acylketene, the stability of which would contribute to the selectivity. The synthetic utility of the dissymmetric S,O-malonates is also shown.
AB - A novel method for the highly selective synthesis of dissymmetric S,O-malonates starting from symmetric diphenyl dithiomalonates under neutral conditions is described. The key step is the thermal formation of an acylketene, the stability of which would contribute to the selectivity. The synthetic utility of the dissymmetric S,O-malonates is also shown.
UR - http://www.scopus.com/inward/record.url?scp=80051673450&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051673450&partnerID=8YFLogxK
U2 - 10.1021/ol201744u
DO - 10.1021/ol201744u
M3 - Article
C2 - 21790154
AN - SCOPUS:80051673450
VL - 13
SP - 4406
EP - 4409
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 16
ER -