Efficient synthesis of dissymmetric malonic acid S, O -esters via monoalcoholysis of symmetric dithiomalonates under neutral conditions

Kazumasa Matsuo, Mitsuru Shindo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A novel method for the highly selective synthesis of dissymmetric S,O-malonates starting from symmetric diphenyl dithiomalonates under neutral conditions is described. The key step is the thermal formation of an acylketene, the stability of which would contribute to the selectivity. The synthetic utility of the dissymmetric S,O-malonates is also shown.

Original languageEnglish
Pages (from-to)4406-4409
Number of pages4
JournalOrganic Letters
Volume13
Issue number16
DOIs
Publication statusPublished - Aug 19 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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