Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases

Yoshio Hayashi, Thomas Regnier, Shigenobu Nishiguchi, Magne O. Sydnes, Daisuke Hashimoto, Junya Hasegawa, Takahiro Katoh, Tetsuya Kajimoto, Masataka Shiozuka, Ryoichi Matsuda, Manabu Node, Yoshiaki Kiso

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Herein, we describe an efficient strategy for the total synthesis of (+)-negamycin using commercially available achiral N-Boc-2-aminoacetaldehyde as starting material with 42% overall yield for a limited number of steps.

Original languageEnglish
Pages (from-to)2379-2381
Number of pages3
JournalChemical Communications
Issue number20
DOIs
Publication statusPublished - 2008

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Hayashi, Y., Regnier, T., Nishiguchi, S., Sydnes, M. O., Hashimoto, D., Hasegawa, J., ... Kiso, Y. (2008). Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases. Chemical Communications, (20), 2379-2381. https://doi.org/10.1039/b801498a