EGFR gets in the way of microRNA biogenesis

Naohiro Nishida, Koshi Mimori, Masaki Mori, George A. Calin

Research output: Contribution to journalArticle

5 Citations (Scopus)


Recent studies suggest that microRNA (miRNA) processing is a key regulatory step in the miRNA biogenesis as well as its transcriptional control. In a paper recently published in Nature, Shen et al. revealed that epidermal growth factor receptor (EGFR) directly interacts with argonaute 2 (AGO2), a critical component of RNA-induced silencing complex (RISC), and inhibits the maturation of specific tumor suppressive miRNAs under hypoxic condition.

Original languageEnglish
Pages (from-to)1157-1158
Number of pages2
JournalCell Research
Issue number10
Publication statusPublished - Oct 1 2013


All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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