EGFR gets in the way of microRNA biogenesis

Naohiro Nishida; Koshi Mimori; Masaki Mori; George A. Calin

doi:10.1038/cr.2013.87

EGFR gets in the way of microRNA biogenesis

Naohiro Nishida, Koshi Mimori, Masaki Mori, George A. Calin

Surgery

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Abstract

Recent studies suggest that microRNA (miRNA) processing is a key regulatory step in the miRNA biogenesis as well as its transcriptional control. In a paper recently published in Nature, Shen et al. revealed that epidermal growth factor receptor (EGFR) directly interacts with argonaute 2 (AGO2), a critical component of RNA-induced silencing complex (RISC), and inhibits the maturation of specific tumor suppressive miRNAs under hypoxic condition.

Original language	English
Pages (from-to)	1157-1158
Number of pages	2
Journal	Cell Research
Volume	23
Issue number	10
DOIs	https://doi.org/10.1038/cr.2013.87
Publication status	Published - Oct 2013

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1038/cr.2013.87

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title = "EGFR gets in the way of microRNA biogenesis",

abstract = "Recent studies suggest that microRNA (miRNA) processing is a key regulatory step in the miRNA biogenesis as well as its transcriptional control. In a paper recently published in Nature, Shen et al. revealed that epidermal growth factor receptor (EGFR) directly interacts with argonaute 2 (AGO2), a critical component of RNA-induced silencing complex (RISC), and inhibits the maturation of specific tumor suppressive miRNAs under hypoxic condition.",

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EGFR gets in the way of microRNA biogenesis

Abstract

All Science Journal Classification (ASJC) codes

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