Abstract
Nanopore sensing via resistive pulse technique are utilized as a potent tool to characterize physical and chemical property of single -molecules and -particles. In this article, we studied the influence of particle trajectory to the ionic conductance through a pore. We performed the optical/electrical simultaneous sensing of electrophoretic capture dynamics of single-particles at a pore using a microchannel/nanopore system. We detected ionic current drops synchronous to a fluorescently dyed particle being electrophoretically drawn and become immobilized at a pore in the optical imaging. We also identified anomalous trapping events wherein particles were captured at nanoscale pin-holes formed unintentionally in a SiN membrane that gave rise to relatively small current drops. This method is expected to be a useful platform for testing novel nanopore sensor design wherein current behaves in unpredictable manner.
Original language | English |
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Article number | 115004 |
Journal | AIP Advances |
Volume | 6 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 1 2016 |
All Science Journal Classification (ASJC) codes
- Physics and Astronomy(all)