Abstract
Nanopore sensing via resistive pulse technique are utilized as a potent tool to characterize physical and chemical property of single -molecules and -particles. In this article, we studied the influence of particle trajectory to the ionic conductance through a pore. We performed the optical/electrical simultaneous sensing of electrophoretic capture dynamics of single-particles at a pore using a microchannel/nanopore system. We detected ionic current drops synchronous to a fluorescently dyed particle being electrophoretically drawn and become immobilized at a pore in the optical imaging. We also identified anomalous trapping events wherein particles were captured at nanoscale pin-holes formed unintentionally in a SiN membrane that gave rise to relatively small current drops. This method is expected to be a useful platform for testing novel nanopore sensor design wherein current behaves in unpredictable manner.
| Original language | English |
|---|---|
| Article number | 115004 |
| Journal | AIP Advances |
| Volume | 6 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 1 2016 |
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All Science Journal Classification (ASJC) codes
- Physics and Astronomy(all)
Cite this
Electrical trapping mechanism of single-microparticles in a pore sensor. / Arima, Akihide; Tsutsui, Makusu; He, Yuhui; Ryuzaki, Sou; Taniguchi, Masateru.
In: AIP Advances, Vol. 6, No. 11, 115004, 01.11.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Electrical trapping mechanism of single-microparticles in a pore sensor
AU - Arima, Akihide
AU - Tsutsui, Makusu
AU - He, Yuhui
AU - Ryuzaki, Sou
AU - Taniguchi, Masateru
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Nanopore sensing via resistive pulse technique are utilized as a potent tool to characterize physical and chemical property of single -molecules and -particles. In this article, we studied the influence of particle trajectory to the ionic conductance through a pore. We performed the optical/electrical simultaneous sensing of electrophoretic capture dynamics of single-particles at a pore using a microchannel/nanopore system. We detected ionic current drops synchronous to a fluorescently dyed particle being electrophoretically drawn and become immobilized at a pore in the optical imaging. We also identified anomalous trapping events wherein particles were captured at nanoscale pin-holes formed unintentionally in a SiN membrane that gave rise to relatively small current drops. This method is expected to be a useful platform for testing novel nanopore sensor design wherein current behaves in unpredictable manner.
AB - Nanopore sensing via resistive pulse technique are utilized as a potent tool to characterize physical and chemical property of single -molecules and -particles. In this article, we studied the influence of particle trajectory to the ionic conductance through a pore. We performed the optical/electrical simultaneous sensing of electrophoretic capture dynamics of single-particles at a pore using a microchannel/nanopore system. We detected ionic current drops synchronous to a fluorescently dyed particle being electrophoretically drawn and become immobilized at a pore in the optical imaging. We also identified anomalous trapping events wherein particles were captured at nanoscale pin-holes formed unintentionally in a SiN membrane that gave rise to relatively small current drops. This method is expected to be a useful platform for testing novel nanopore sensor design wherein current behaves in unpredictable manner.
UR - http://www.scopus.com/inward/record.url?scp=84994032930&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84994032930&partnerID=8YFLogxK
U2 - 10.1063/1.4967214
DO - 10.1063/1.4967214
M3 - Article
AN - SCOPUS:84994032930
VL - 6
JO - AIP Advances
JF - AIP Advances
SN - 2158-3226
IS - 11
M1 - 115004
ER -