Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension

Keimei Yoshida, Keita Saku, Kazuhiro Kamada, Kotaro Abe, Mariko Tanaka-Ishikawa, Takeshi Tohyama, Takuya Nishikawa, Takuya Kishi, Kenji Sunagawa, Hiroyuki Tsutsui

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study aimed to elucidate the therapeutic effects of electrical vagal nerve stimulation (VNS) on severe pulmonary arterial hypertension in a rat model. In a pathophysiological study, VNS significantly restored autonomic balance, decreased mean pulmonary arterial pressure, attenuated pulmonary vascular remodeling, and preserved right ventricular function. In a survival study, VNS significantly improved the survival rate in both the prevention (VNS from 0 to 5 weeks after a SU5416 injection) and treatment (VNS from 5 to 10 weeks) protocols. Thus, VNS may serve as a novel therapeutic strategy for pulmonary arterial hypertension.

Original languageEnglish
Pages (from-to)657-671
Number of pages15
JournalJACC: Basic to Translational Science
Volume3
Issue number5
DOIs
Publication statusPublished - Oct 1 2018

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Vagus Nerve Stimulation
Pulmonary Hypertension
Lung
Right Ventricular Function
Therapeutic Uses
Vascular Remodeling
Arterial Pressure
Injections
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension. / Yoshida, Keimei; Saku, Keita; Kamada, Kazuhiro; Abe, Kotaro; Tanaka-Ishikawa, Mariko; Tohyama, Takeshi; Nishikawa, Takuya; Kishi, Takuya; Sunagawa, Kenji; Tsutsui, Hiroyuki.

In: JACC: Basic to Translational Science, Vol. 3, No. 5, 01.10.2018, p. 657-671.

Research output: Contribution to journalArticle

Yoshida, Keimei ; Saku, Keita ; Kamada, Kazuhiro ; Abe, Kotaro ; Tanaka-Ishikawa, Mariko ; Tohyama, Takeshi ; Nishikawa, Takuya ; Kishi, Takuya ; Sunagawa, Kenji ; Tsutsui, Hiroyuki. / Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension. In: JACC: Basic to Translational Science. 2018 ; Vol. 3, No. 5. pp. 657-671.
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