Electrochemical preparation of a reduced graphene oxide/ruthenium oxide modified electrode and its application to the simultaneous determination of serotonin and melatonin

Balamurugan Devadas, Rajesh Madhu, Shen Ming Chen, Vediyappan Veeramani, Muniyandi Rajkumar

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Herein, we report the simultaneous voltammetric determination of serotonin (5-HT) and melatonin (MET) using a reduced graphene oxide/ruthenium oxide (RGO/RuO2) modified glassy carbon electrode (GCE) for the first time. The as-synthesized RGO/RuO2 composites were characterized by using a variety of techniques, such as scanning electron microscopy (SEM), infrared spectroscopy (IR), X-ray diffraction (XRD), Raman spectroscopy and energy dispersive X-ray spectroscopy (EDX). An enhanced voltammetric oxidation peak was observed for serotonin (5-HT) and melatonin (MET) at RGO/RuO2 modified GCE. Notably, a sufficient voltammetric peak to peak separation (δEp) of 290 mV was found between the two species by using differential pulse voltammetry (DPV) analysis. The lower limit of detection (LOD) was calculated as 0.02 μM for 5-HT and 0.18 μM for MET. Moreover, the fabricated sensor was found to exhibit excellent sensitivity, reliability, and durability, surpassing those achievable with other modified electrodes, which may find use in practical industrial applications.

Original languageEnglish
Pages (from-to)654-662
Number of pages9
JournalScience of Advanced Materials
Volume7
Issue number4
DOIs
Publication statusPublished - 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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