Electrochemical Synthesis of Cyanoformamides from Trichloroacetonitrile and Secondary Amines Mediated by the B12Derivative

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Abstract

The B12derivative, heptamethyl cobyrinate, -mediated electrochemical synthesis of cyanoformamides has been developed. Aerobic oxygenation of the carbon-centered radical initiatedin situgeneration of the reactive acyl chloride intermediate, which led to cyanoformamides in the presence of an amine. This one-pot and scalable synthetic method has been demonstrated with 41 examples up to 94% yields with 21 new compounds. The mechanism of electrolysis mediated by the B12derivative has been proposed based on the DFT calculations.

Original languageEnglish
Pages (from-to)16134-16143
Number of pages10
JournalJournal of Organic Chemistry
Volume86
Issue number22
DOIs
Publication statusPublished - Nov 19 2021

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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