Electrochemically driven, cobalt-carbon bond-mediated direct intramolecular cyclic and acyclic perfluoroalkylation of (hetero)arenes using X(CF2)4X

Luxia Cui, Toshikazu Ono, Md Jakir Hossain, Yoshio Hisaeda

Research output: Contribution to journalArticle

Abstract

A proof-of-concept for the one-step, synthetically challenging cyclic and acyclic perfluoroalkylation of (hetero)arenes driven by the valence change of a vitamin B12 derivative as a cobalt catalyst in the presence of fluoroalkylating reagents (X(CF2)4X) is presented. The consecutive formation of cobalt-carbon bonds and generation of fluoroalkyl radicals by homolysis are the key steps for the reaction to proceed.

Original languageEnglish
Pages (from-to)24862-24866
Number of pages5
JournalRSC Advances
Volume10
Issue number42
DOIs
Publication statusPublished - Jun 30 2020

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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