Electron spin resonance spectroscopy studies on 15N-labeled and their deuterated nitroxyl spin probes used in molecular imaging

D. David Jebaraj, A. Milton Franklin Benial, Kazuhiro Ichikawa, Ken-Ichi Yamada, Hideo Utsumi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Electron Spin Resonance (ESR) studies were carried out for 2 mM concentration of 15N labeled carbamoyl-PROXYL, carboxy-PROXYL, MC-PROXYL and their deuterated derivatives using X-band ESR spectrometer. The ESR parameters such as linewidth, hyperfine coupling constant, g-factor, spin-spin relaxation time were determined. The lineshape analysis was also carried out. The observed linewidth values are ̃50% higher for undeuterated nitroxyl radicals compared with their deuterated derivatives. The lineshape analysis reveals that the observed ESR lineshape is a voigt lineshape, which is the convolution of a lorentzian and guassian profile. ESR lineshape analysis results that the lorentzian contribution is ̃20% higher for deuterated nitroxyl radicals compared with undeuterated nitroxyl radicals. The observed spin-spin relaxartion time for deuterated nitroxyl radicals is ̃50% longer compared with undeuterated nitroxyl radicals. The g value indicates the isotropic nature of nitroxyl radicals in pure water. From these results, the deuterated nitroxyl radicals are suitable spin probes for ESR/Overhauser- enhanced magnetic resonance (OMR) studies.

Original languageEnglish
Title of host publicationProceeding of International Conference on Recent Trends in Applied Physics and Material Science, RAM 2013
Pages1171-1172
Number of pages2
DOIs
Publication statusPublished - Jul 18 2013
EventInternational Conference on Recent Trends in Applied Physics and Material Science, RAM 2013 - Bikaner, Rajasthan, India
Duration: Feb 1 2013Feb 2 2013

Publication series

NameAIP Conference Proceedings
Volume1536
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

OtherInternational Conference on Recent Trends in Applied Physics and Material Science, RAM 2013
CountryIndia
CityBikaner, Rajasthan
Period2/1/132/2/13

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All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

Cite this

Jebaraj, D. D., Benial, A. M. F., Ichikawa, K., Yamada, K-I., & Utsumi, H. (2013). Electron spin resonance spectroscopy studies on 15N-labeled and their deuterated nitroxyl spin probes used in molecular imaging. In Proceeding of International Conference on Recent Trends in Applied Physics and Material Science, RAM 2013 (pp. 1171-1172). (AIP Conference Proceedings; Vol. 1536). https://doi.org/10.1063/1.4810655