Electron spin resonance spectroscopy studies on 15N-labeled and their deuterated nitroxyl spin probes used in molecular imaging

D. David Jebaraj, A. Milton Franklin Benial, Kazuhiro Ichikawa, Ken-Ichi Yamada, Hideo Utsumi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Electron Spin Resonance (ESR) studies were carried out for 2 mM concentration of 15N labeled carbamoyl-PROXYL, carboxy-PROXYL, MC-PROXYL and their deuterated derivatives using X-band ESR spectrometer. The ESR parameters such as linewidth, hyperfine coupling constant, g-factor, spin-spin relaxation time were determined. The lineshape analysis was also carried out. The observed linewidth values are ̃50% higher for undeuterated nitroxyl radicals compared with their deuterated derivatives. The lineshape analysis reveals that the observed ESR lineshape is a voigt lineshape, which is the convolution of a lorentzian and guassian profile. ESR lineshape analysis results that the lorentzian contribution is ̃20% higher for deuterated nitroxyl radicals compared with undeuterated nitroxyl radicals. The observed spin-spin relaxartion time for deuterated nitroxyl radicals is ̃50% longer compared with undeuterated nitroxyl radicals. The g value indicates the isotropic nature of nitroxyl radicals in pure water. From these results, the deuterated nitroxyl radicals are suitable spin probes for ESR/Overhauser- enhanced magnetic resonance (OMR) studies.

Original languageEnglish
Title of host publicationProceeding of International Conference on Recent Trends in Applied Physics and Material Science, RAM 2013
Pages1171-1172
Number of pages2
DOIs
Publication statusPublished - Jul 18 2013
EventInternational Conference on Recent Trends in Applied Physics and Material Science, RAM 2013 - Bikaner, Rajasthan, India
Duration: Feb 1 2013Feb 2 2013

Publication series

NameAIP Conference Proceedings
Volume1536
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

OtherInternational Conference on Recent Trends in Applied Physics and Material Science, RAM 2013
CountryIndia
CityBikaner, Rajasthan
Period2/1/132/2/13

Fingerprint

electron paramagnetic resonance
probes
spectroscopy
superhigh frequencies
convolution integrals
magnetic resonance
relaxation time
spectrometers
profiles
water

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

Cite this

Jebaraj, D. D., Benial, A. M. F., Ichikawa, K., Yamada, K-I., & Utsumi, H. (2013). Electron spin resonance spectroscopy studies on 15N-labeled and their deuterated nitroxyl spin probes used in molecular imaging. In Proceeding of International Conference on Recent Trends in Applied Physics and Material Science, RAM 2013 (pp. 1171-1172). (AIP Conference Proceedings; Vol. 1536). https://doi.org/10.1063/1.4810655

Electron spin resonance spectroscopy studies on 15N-labeled and their deuterated nitroxyl spin probes used in molecular imaging. / Jebaraj, D. David; Benial, A. Milton Franklin; Ichikawa, Kazuhiro; Yamada, Ken-Ichi; Utsumi, Hideo.

Proceeding of International Conference on Recent Trends in Applied Physics and Material Science, RAM 2013. 2013. p. 1171-1172 (AIP Conference Proceedings; Vol. 1536).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Jebaraj, DD, Benial, AMF, Ichikawa, K, Yamada, K-I & Utsumi, H 2013, Electron spin resonance spectroscopy studies on 15N-labeled and their deuterated nitroxyl spin probes used in molecular imaging. in Proceeding of International Conference on Recent Trends in Applied Physics and Material Science, RAM 2013. AIP Conference Proceedings, vol. 1536, pp. 1171-1172, International Conference on Recent Trends in Applied Physics and Material Science, RAM 2013, Bikaner, Rajasthan, India, 2/1/13. https://doi.org/10.1063/1.4810655
Jebaraj DD, Benial AMF, Ichikawa K, Yamada K-I, Utsumi H. Electron spin resonance spectroscopy studies on 15N-labeled and their deuterated nitroxyl spin probes used in molecular imaging. In Proceeding of International Conference on Recent Trends in Applied Physics and Material Science, RAM 2013. 2013. p. 1171-1172. (AIP Conference Proceedings). https://doi.org/10.1063/1.4810655
Jebaraj, D. David ; Benial, A. Milton Franklin ; Ichikawa, Kazuhiro ; Yamada, Ken-Ichi ; Utsumi, Hideo. / Electron spin resonance spectroscopy studies on 15N-labeled and their deuterated nitroxyl spin probes used in molecular imaging. Proceeding of International Conference on Recent Trends in Applied Physics and Material Science, RAM 2013. 2013. pp. 1171-1172 (AIP Conference Proceedings).
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