Electroretinograms to checkerboard pattern reversal in cats: physiological characteristics and effect of retrograde degeneration of ganglion cells

Shozo Tobimatsu, Gastone G. Celesia, Sandra Cone, Meena Gujrati

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Pattern electroretinograms (P-ERGs) evoked by alternating checks were studied in cats. Spatial frequency functions for transient and steady-state P-ERG waves showed a bimodal distribution with a preferred frequency at 0.6-0.75 c/deg and a second amplitude increase at frequencies lower than 0.5 c/deg. Decreasing the pattern luminance by 0.5 log units produced a shift of the spatial tuning curve toward lower spatial frequencies. No temporal tuning was noted in the temporal frequency functions. The bimodal distribution suggests that at spatial frequencies higher than 0.5 c/deg, the tuning reflects a 'contrast response' originating in cells with center surround organization. At spatial frequencies below 0.5 c/deg, the 'luminance response' becomes predominant and is generated in cells sensitive to mean luminance changes. Transient and steady-state P-ERGs to medium and high spatial frequencies were abolished by section of the optic nerve, while low spatial frequency stimuli at or below 0.3 c/deg continued to evoke P-ERGs at 1, 5 and 10 months after surgery. Quantitative whole amount retina microscopic examination confirmed the retrograde degeneration of the ganglion cells. It is concluded that both transient and steady-state P-ERGs to small and medium spatial frequencies checks are predominantly related to ganglion cell activity, while P-ERGs to low spatial frequencies reflect preganglionic cell activity.

Original languageEnglish
Pages (from-to)341-352
Number of pages12
JournalElectroencephalography and Clinical Neurophysiology
Volume73
Issue number4
DOIs
Publication statusPublished - Jan 1 1989
Externally publishedYes

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Retrograde Degeneration
Ganglia
Cats
Optic Nerve
Retina

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Electroretinograms to checkerboard pattern reversal in cats : physiological characteristics and effect of retrograde degeneration of ganglion cells. / Tobimatsu, Shozo; Celesia, Gastone G.; Cone, Sandra; Gujrati, Meena.

In: Electroencephalography and Clinical Neurophysiology, Vol. 73, No. 4, 01.01.1989, p. 341-352.

Research output: Contribution to journalArticle

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