TY - JOUR
T1 - Electrospun nano- to microfiber fabrics made of biodegradable copolyesters
T2 - Structural characteristics, mechanical properties and cell adhesion potential
AU - Keun Kwon, Il
AU - Kidoaki, Satoru
AU - Matsuda, Takehisa
N1 - Funding Information:
The authors thank Dr. T. Kanemaru of the Faculty of Medicine, Kyushu University, for SEM. This study was financially supported in part by a Grant-in-Aid for Scientific Research (A2-15200038) from Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan.
PY - 2005/6
Y1 - 2005/6
N2 - Nano- to micro-structured biodegradable poly(l-lactide-co-ε- caprolactone) (PLCL) fabrics were prepared by electrospinning. Electrospun microfiber fabrics with different compositions of PLCL (mol% in feed; 70/30, 50/50, and 30/70), poly(l-lactide) (PLL) and poly(ε-caprolactone) (PCL) were obtained using methylene chloride (MC) as a solvent. The PLL microfiber exhibited a nanoscale-pore structure with a pore diameter of approximately 200-800 nm at the surface and subsurface regions, whereas such a surface structure was hardly observed in other polymers containing CL. The microfiber fabric made of PLCL 50/50 was elastomeric. Nanoscale-fiber fabrics with PLCL 50/50 (approx. 0.3 or 1.2 μm in diameter) were electrospun using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as a solvent. Mercury porosimetry showed that the decrease in the fiber diameter of the fabric decreased porosity, but increased fiber density and mechanical strength. Human umbilical vein endothelial cells (HUVECs) were adhered well and proliferated on the small-diameter-fiber fabrics (0.3 and 1.2 μm in diameter), both of which are dense fabrics, whereas markedly reduced cell adhesion, restricted cell spreading and no signs of proliferation were observed on the large-diameter-fiber fabric (7.0 μm in diameter). The potential biomedical application of electrospun PLCL 50/50 was discussed.
AB - Nano- to micro-structured biodegradable poly(l-lactide-co-ε- caprolactone) (PLCL) fabrics were prepared by electrospinning. Electrospun microfiber fabrics with different compositions of PLCL (mol% in feed; 70/30, 50/50, and 30/70), poly(l-lactide) (PLL) and poly(ε-caprolactone) (PCL) were obtained using methylene chloride (MC) as a solvent. The PLL microfiber exhibited a nanoscale-pore structure with a pore diameter of approximately 200-800 nm at the surface and subsurface regions, whereas such a surface structure was hardly observed in other polymers containing CL. The microfiber fabric made of PLCL 50/50 was elastomeric. Nanoscale-fiber fabrics with PLCL 50/50 (approx. 0.3 or 1.2 μm in diameter) were electrospun using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as a solvent. Mercury porosimetry showed that the decrease in the fiber diameter of the fabric decreased porosity, but increased fiber density and mechanical strength. Human umbilical vein endothelial cells (HUVECs) were adhered well and proliferated on the small-diameter-fiber fabrics (0.3 and 1.2 μm in diameter), both of which are dense fabrics, whereas markedly reduced cell adhesion, restricted cell spreading and no signs of proliferation were observed on the large-diameter-fiber fabric (7.0 μm in diameter). The potential biomedical application of electrospun PLCL 50/50 was discussed.
UR - http://www.scopus.com/inward/record.url?scp=11144281219&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11144281219&partnerID=8YFLogxK
U2 - 10.1016/j.biomaterials.2004.10.007
DO - 10.1016/j.biomaterials.2004.10.007
M3 - Article
C2 - 15626440
AN - SCOPUS:11144281219
VL - 26
SP - 3929
EP - 3939
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 18
ER -