TY - JOUR
T1 - Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese multiple sclerosis
AU - Hayashi, Fumie
AU - Isobe, Noriko
AU - Cossu, Davide
AU - Yokoyama, Kazumasa
AU - Sakoda, Ayako
AU - Matsushita, Takuya
AU - Hattori, Nobutaka
AU - Kira, Jun ichi
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research (C) (JSPS KAKENHI Grant Number 16H02657 ) from the Japan Society for the Promotion of Science . We thank Edanz Group ( https://en-author-services.edanz.com/ac ) for editing a draft of this manuscript.
Publisher Copyright:
© 2021 The Authors
PY - 2021/11/15
Y1 - 2021/11/15
N2 - To investigate whether antibody production against mycobacterium avium subsp. paratuberculosis (MAP) is related to clinical characteristics of multiple sclerosis (MS) and human leukocyte antigen (HLA) alleles, IgG antibody against three MAP peptides and two human peptides homologous to MAP were measured in sera from 103 MS patients and 50 healthy controls (HCs). MS patients had higher IgG levels against MAP2694295–303 (MAP2694-IgG) than HCs, while the other antibodies were comparable. Multivariate analysis demonstrated that higher MAP2694-IgG titers were associated with higher EDSS scores, but not with HLA alleles or dairy product consumption. Immune response against MAP may worsen MS disability.
AB - To investigate whether antibody production against mycobacterium avium subsp. paratuberculosis (MAP) is related to clinical characteristics of multiple sclerosis (MS) and human leukocyte antigen (HLA) alleles, IgG antibody against three MAP peptides and two human peptides homologous to MAP were measured in sera from 103 MS patients and 50 healthy controls (HCs). MS patients had higher IgG levels against MAP2694295–303 (MAP2694-IgG) than HCs, while the other antibodies were comparable. Multivariate analysis demonstrated that higher MAP2694-IgG titers were associated with higher EDSS scores, but not with HLA alleles or dairy product consumption. Immune response against MAP may worsen MS disability.
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U2 - 10.1016/j.jneuroim.2021.577701
DO - 10.1016/j.jneuroim.2021.577701
M3 - Article
C2 - 34507015
AN - SCOPUS:85114419659
VL - 360
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
SN - 0165-5728
M1 - 577701
ER -
