Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis

Hirofumi Inoue, Takeshi Matsushige, Takashi Ichiyama, Alato Okuno, Osamu Takikawa, Shozo Tomonaga, Banu Anlar, Deniz Yüksel, Yasushi Otsuka, Fumitaka Kohno, Madoka Hoshide, Shouichi Ohga, Shunji Hasegawa

Research output: Contribution to journalArticle

Abstract

Subacute sclerosing panencephalitis (SSPE) is a rare neurodegenerative disorder caused by a persistent infection with aberrant measles virus. Indoleamine-2, 3-dioxygenase (IDO) initiates the increased production of kynurenine pathway (KP) metabolites quinolinic acid (QUIN), which has an excitotoxic effect for neurons. We measured serum IDO activity and cerebrospinal fluid (CSF) levels of QUIN. The CSF QUIN levels were significantly higher in SSPE patients than in controls, and increased according as neurological disability in a patient studied. Elevation of CSF QUIN and progression of SSPE indicate a pathological role of KP metabolism in the inflammatory neurodestruction.

Original languageEnglish
Article number577088
JournalJournal of Neuroimmunology
Volume339
DOIs
Publication statusPublished - Feb 15 2020

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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    Inoue, H., Matsushige, T., Ichiyama, T., Okuno, A., Takikawa, O., Tomonaga, S., Anlar, B., Yüksel, D., Otsuka, Y., Kohno, F., Hoshide, M., Ohga, S., & Hasegawa, S. (2020). Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis. Journal of Neuroimmunology, 339, [577088]. https://doi.org/10.1016/j.jneuroim.2019.577088