Embolic complications associated with neurovascular intervention: Prospective evaluation by use of diffusion-weighted MR imaging

Hideki Sakai, Nobuyuki Sakai, Toshio Higashi, Koji Iihara, Jun Takahashi, Shuji Kogure, Ryogo Anei, Naoaki Yamada, Satoshi Imakita, Izumi Nagata

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Abstract

The most serious complication of neurovascular interventions is distal cerebral embolism. Diffusion-weighted MR imaging (DWI) appears to be the most sensitive technique for detecting early and small ischemic lesions. To evaluatethe incidence and radiological features of embolic events associated with neuro-intervention, we applied DWI to screening for procedure-related ischemiclesions including silent embolisms. One hundred and thirty-seven patients who have received 154 neuro-interventional procedures were studied with DWI before and within 5 days after treatment. Imaging was performed, using single-shot echo-planar imaging with b value of 1000-1100 sec/mm2. DWI findings were classified into 5 groups by size and location of lesions: type 0 (n=71), no lesions; I (n=33), lesions in border-zone regions only; II (n=9), lesions at perforator territories mainly; III (n=29), small territorial lesions (< 5 mm); IV (n= 12), large territorial lesions (≥ 5 mm). DWI detected procedure-relatedlesions in 83 of 154 procedures (53.9%), 36 of which demonstrated new neurological symptoms during and/or after procedures. The parent artery occlusion for cerebral aneurysms had a higher incidence of symptomatic embolisms than other procedures. In 71 of 154 procedures (46.1%), DWI detected no lesions(type 0). Although type I was the most frequent pattern presented, it included few neurological symptoms. Type III often resulted in transient symptoms, and type II and IV tended to induce strokes. Because ischemic lesions detected by DWI were likely to arise in border-zone territories by parent artery occlusions, we considered that hypoperfusion as well as emboli were involved in theevolution of cerebral infarctions. Thus, DWI is a useful method to detect silent embolisms, and to determine the safety of neurointervention and the mechanism of embolic ischemia.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalNeurological Surgery
Volume30
Issue number1
Publication statusPublished - Feb 6 2002

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Embolism
Arteries
Echo-Planar Imaging
Intracranial Embolism
Incidence
Cerebral Infarction
Intracranial Aneurysm
Ischemia
Stroke
Safety
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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Embolic complications associated with neurovascular intervention : Prospective evaluation by use of diffusion-weighted MR imaging. / Sakai, Hideki; Sakai, Nobuyuki; Higashi, Toshio; Iihara, Koji; Takahashi, Jun; Kogure, Shuji; Anei, Ryogo; Yamada, Naoaki; Imakita, Satoshi; Nagata, Izumi.

In: Neurological Surgery, Vol. 30, No. 1, 06.02.2002, p. 43-49.

Research output: Contribution to journalArticle

Sakai, H, Sakai, N, Higashi, T, Iihara, K, Takahashi, J, Kogure, S, Anei, R, Yamada, N, Imakita, S & Nagata, I 2002, 'Embolic complications associated with neurovascular intervention: Prospective evaluation by use of diffusion-weighted MR imaging', Neurological Surgery, vol. 30, no. 1, pp. 43-49.
Sakai, Hideki ; Sakai, Nobuyuki ; Higashi, Toshio ; Iihara, Koji ; Takahashi, Jun ; Kogure, Shuji ; Anei, Ryogo ; Yamada, Naoaki ; Imakita, Satoshi ; Nagata, Izumi. / Embolic complications associated with neurovascular intervention : Prospective evaluation by use of diffusion-weighted MR imaging. In: Neurological Surgery. 2002 ; Vol. 30, No. 1. pp. 43-49.
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