Embryonic regulation of the mouse hematopoietic niche

Daisuke Sugiyama, Tomoko Inoue-Yokoo, Stuart T. Fraser, Kasem Kulkeaw, Chiyo Mizuochi, Yuka Horio

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Hematopoietic stem cells (HSCs) can differentiate into several types of hematopoietic cells (HCs) (such as erythrocytes, megakaryocytes, lymphocytes, neutrophils, or macrophages) and also undergo self-renewal to sustain hematopoiesis throughout an organism's lifetime. HSCs are currently used clinically as transplantation therapy in regenerative medicine and are typically obtained from healthy donors or cord blood. However, problems remain in HSC transplantation, such as shortage of cells, donor risks, rejection, and graft-versus-host disease (GVHD). Thus, increased understanding of HSC regulation should enable us to improve HSC therapy and develop novel regenerative medicine techniques. HSC regulation is governed by two types of activity: intrinsic regulation, programmed primarily by cell autonomous gene expression, and extrinsic factors, which originate from so-called niche cells surrounding HSCs. Here, we focus on the latter and discuss HSC regulation with special emphasis on the role played by niche cells.

Original languageEnglish
Pages (from-to)1770-1780
Number of pages11
JournalTheScientificWorldJournal
Volume11
DOIs
Publication statusPublished - Nov 23 2011

Fingerprint

Hematopoietic Stem Cells
Stem cells
niche
stem
Regenerative Medicine
transplantation
medicine
Megakaryocytes
Hematopoietic Stem Cell Transplantation
Hematopoiesis
Graft vs Host Disease
Cell- and Tissue-Based Therapy
Lymphocytes
regulation
Macrophages
Fetal Blood
Gene expression
Grafts
Neutrophils
gene expression

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

Cite this

Sugiyama, D., Inoue-Yokoo, T., Fraser, S. T., Kulkeaw, K., Mizuochi, C., & Horio, Y. (2011). Embryonic regulation of the mouse hematopoietic niche. TheScientificWorldJournal, 11, 1770-1780. https://doi.org/10.1100/2011/598097

Embryonic regulation of the mouse hematopoietic niche. / Sugiyama, Daisuke; Inoue-Yokoo, Tomoko; Fraser, Stuart T.; Kulkeaw, Kasem; Mizuochi, Chiyo; Horio, Yuka.

In: TheScientificWorldJournal, Vol. 11, 23.11.2011, p. 1770-1780.

Research output: Contribution to journalArticle

Sugiyama, D, Inoue-Yokoo, T, Fraser, ST, Kulkeaw, K, Mizuochi, C & Horio, Y 2011, 'Embryonic regulation of the mouse hematopoietic niche', TheScientificWorldJournal, vol. 11, pp. 1770-1780. https://doi.org/10.1100/2011/598097
Sugiyama D, Inoue-Yokoo T, Fraser ST, Kulkeaw K, Mizuochi C, Horio Y. Embryonic regulation of the mouse hematopoietic niche. TheScientificWorldJournal. 2011 Nov 23;11:1770-1780. https://doi.org/10.1100/2011/598097
Sugiyama, Daisuke ; Inoue-Yokoo, Tomoko ; Fraser, Stuart T. ; Kulkeaw, Kasem ; Mizuochi, Chiyo ; Horio, Yuka. / Embryonic regulation of the mouse hematopoietic niche. In: TheScientificWorldJournal. 2011 ; Vol. 11. pp. 1770-1780.
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