Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis

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33 Citations (Scopus)

Abstract

Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (TH2)-deviated immune reactions. Interleukin-31 (IL-31), preferentially produced from TH2 cells, is a potent pruritogenic cytokine, and its systemic and local administration induces scratching behavior in rodents, dogs and monkeys. Recent clinical trials have revealed that administration of an anti-IL-31 receptor antibody significantly alleviates pruritus in patients with AD. In this review, we summarize recent topics related to IL-31 and its receptor with special references to atopic itch.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume73
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

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Interleukin Receptors
Interleukins
Atopic Dermatitis
Pruritus
Skin
Th2 Cells
Haplorhini
Rodentia
Clinical Trials
Dogs
Cytokines
Antibodies

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

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abstract = "Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (TH2)-deviated immune reactions. Interleukin-31 (IL-31), preferentially produced from TH2 cells, is a potent pruritogenic cytokine, and its systemic and local administration induces scratching behavior in rodents, dogs and monkeys. Recent clinical trials have revealed that administration of an anti-IL-31 receptor antibody significantly alleviates pruritus in patients with AD. In this review, we summarize recent topics related to IL-31 and its receptor with special references to atopic itch.",
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AU - Furue, Masutaka

AU - Yamamura, K.

AU - Nakahara, Makiko

AU - Nakahara, Takeshi

AU - Fukui, Yoshinori

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