EML4-ALK fusion transcript is not found in gastrointestinal and breast cancers

Y. Fukuyoshi, H. Inoue, Y. Kita, T. Utsunomiya, T. Ishida, Masaki Mori

Research output: Contribution to journalArticle

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Abstract

Fusion genes have been identified as chromosomal rearrangements in certain cancers, such as leukaemia, lymphoma, and sarcoma. The EML4-ALK (EML4: echinoderm microtubule-associated-protein-like 4; ALK: anaplastic lymphoma kinase) fusion gene has been identified as an oncogene in non-small-cell lung cancer (NSCLC). This study examined the presence of this fusion transcript in gastrointestinal and breast cancers. We evaluated the expression of the EML4-ALK transcript in 104 lung cancer cases and in 645 gastrointestinal and breast cancer samples. Only one of the lung cancer samples tested positive for the EML4-ALK fusion transcript, whereas none were detected in 555 gastrointestinal and 90 breast cancer cases. Our data suggest that the EML4-ALK fusion transcript is not present in gastrointestinal or breast cancers and is specific to NSCLC.

Original languageEnglish
Pages (from-to)1536-1539
Number of pages4
JournalBritish journal of cancer
Volume98
Issue number9
DOIs
Publication statusPublished - May 6 2008

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Gastrointestinal Neoplasms
Breast Neoplasms
Gene Fusion
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Oncogenes
Sarcoma
Lymphoma
Leukemia
MAP4
anaplastic lymphoma kinase
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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EML4-ALK fusion transcript is not found in gastrointestinal and breast cancers. / Fukuyoshi, Y.; Inoue, H.; Kita, Y.; Utsunomiya, T.; Ishida, T.; Mori, Masaki.

In: British journal of cancer, Vol. 98, No. 9, 06.05.2008, p. 1536-1539.

Research output: Contribution to journalArticle

Fukuyoshi, Y, Inoue, H, Kita, Y, Utsunomiya, T, Ishida, T & Mori, M 2008, 'EML4-ALK fusion transcript is not found in gastrointestinal and breast cancers', British journal of cancer, vol. 98, no. 9, pp. 1536-1539. https://doi.org/10.1038/sj.bjc.6604341
Fukuyoshi, Y. ; Inoue, H. ; Kita, Y. ; Utsunomiya, T. ; Ishida, T. ; Mori, Masaki. / EML4-ALK fusion transcript is not found in gastrointestinal and breast cancers. In: British journal of cancer. 2008 ; Vol. 98, No. 9. pp. 1536-1539.
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