Abstract
Fusion genes have been identified as chromosomal rearrangements in certain cancers, such as leukaemia, lymphoma, and sarcoma. The EML4-ALK (EML4: echinoderm microtubule-associated-protein-like 4; ALK: anaplastic lymphoma kinase) fusion gene has been identified as an oncogene in non-small-cell lung cancer (NSCLC). This study examined the presence of this fusion transcript in gastrointestinal and breast cancers. We evaluated the expression of the EML4-ALK transcript in 104 lung cancer cases and in 645 gastrointestinal and breast cancer samples. Only one of the lung cancer samples tested positive for the EML4-ALK fusion transcript, whereas none were detected in 555 gastrointestinal and 90 breast cancer cases. Our data suggest that the EML4-ALK fusion transcript is not present in gastrointestinal or breast cancers and is specific to NSCLC.
| Original language | English |
|---|---|
| Pages (from-to) | 1536-1539 |
| Number of pages | 4 |
| Journal | British journal of cancer |
| Volume | 98 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - May 6 2008 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
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EML4-ALK fusion transcript is not found in gastrointestinal and breast cancers. / Fukuyoshi, Y.; Inoue, H.; Kita, Y.; Utsunomiya, T.; Ishida, T.; Mori, Masaki.
In: British journal of cancer, Vol. 98, No. 9, 06.05.2008, p. 1536-1539.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - EML4-ALK fusion transcript is not found in gastrointestinal and breast cancers
AU - Fukuyoshi, Y.
AU - Inoue, H.
AU - Kita, Y.
AU - Utsunomiya, T.
AU - Ishida, T.
AU - Mori, Masaki
PY - 2008/5/6
Y1 - 2008/5/6
N2 - Fusion genes have been identified as chromosomal rearrangements in certain cancers, such as leukaemia, lymphoma, and sarcoma. The EML4-ALK (EML4: echinoderm microtubule-associated-protein-like 4; ALK: anaplastic lymphoma kinase) fusion gene has been identified as an oncogene in non-small-cell lung cancer (NSCLC). This study examined the presence of this fusion transcript in gastrointestinal and breast cancers. We evaluated the expression of the EML4-ALK transcript in 104 lung cancer cases and in 645 gastrointestinal and breast cancer samples. Only one of the lung cancer samples tested positive for the EML4-ALK fusion transcript, whereas none were detected in 555 gastrointestinal and 90 breast cancer cases. Our data suggest that the EML4-ALK fusion transcript is not present in gastrointestinal or breast cancers and is specific to NSCLC.
AB - Fusion genes have been identified as chromosomal rearrangements in certain cancers, such as leukaemia, lymphoma, and sarcoma. The EML4-ALK (EML4: echinoderm microtubule-associated-protein-like 4; ALK: anaplastic lymphoma kinase) fusion gene has been identified as an oncogene in non-small-cell lung cancer (NSCLC). This study examined the presence of this fusion transcript in gastrointestinal and breast cancers. We evaluated the expression of the EML4-ALK transcript in 104 lung cancer cases and in 645 gastrointestinal and breast cancer samples. Only one of the lung cancer samples tested positive for the EML4-ALK fusion transcript, whereas none were detected in 555 gastrointestinal and 90 breast cancer cases. Our data suggest that the EML4-ALK fusion transcript is not present in gastrointestinal or breast cancers and is specific to NSCLC.
UR - http://www.scopus.com/inward/record.url?scp=43249099270&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43249099270&partnerID=8YFLogxK
U2 - 10.1038/sj.bjc.6604341
DO - 10.1038/sj.bjc.6604341
M3 - Article
C2 - 18414414
AN - SCOPUS:43249099270
VL - 98
SP - 1536
EP - 1539
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 9
ER -