Empyema following the percutaneous instillation of antifungal agents in patients with aspergillosis

Yoichi Nakanishi, Kentaro Wakamatsu, Yoshitsugu Nomoto, Masayuki Kawasaki, Koichi Takayama, Jun Yatsunami, Nobuko Tsuruta, Shuichi Hashimoto, Nobuyuki Hara

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Abstract

We report two cases of empyema as a complication of the percutaneous instillation of antifungal drugs for pulmonary and pleural aspergillosis. Case 1 underwent percutaneous administration of amphotericin B and fluconazole for 2 months. Six months later, the patient was found to have an Aspergillus empyema with a bronchopleural fistula. Case 2 with pulmonary and pleural aspergillosis underwent percutaneous administration of amphotericin B for one month. Four months later, the patient underwent pleural drainage due to empyema. Fleural biopsy revealed pleural aspergillosis. In both cases, it was suggested that the preceding Aspergillus infection and percutaneous instillation of antifungals resulted in the development of empyema.

Original languageEnglish
Pages (from-to)657-659
Number of pages3
JournalInternal Medicine
Volume35
Issue number8
DOIs
Publication statusPublished - Aug 1996

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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    Nakanishi, Y., Wakamatsu, K., Nomoto, Y., Kawasaki, M., Takayama, K., Yatsunami, J., Tsuruta, N., Hashimoto, S., & Hara, N. (1996). Empyema following the percutaneous instillation of antifungal agents in patients with aspergillosis. Internal Medicine, 35(8), 657-659. https://doi.org/10.2169/internalmedicine.35.657