Enantioselective [2,3]-Wittig rearrangement induced by asymmetric lithiation with a t-butyllithium / chiral bis(oxazoline) system

Katsuhiko Tomooka, Nobuyuki Komine, Takeshi Nakai

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

The [2,3]-Wittig rearrangement of (E)-crotyl propargylic ethers, when induced with a t-BuLi / chiral bis(oxazoline) complex, is shown to provide high enantioselectivity (up to 89% ee) along with high diastereoselectivity.

Original languageEnglish
Pages (from-to)5513-5516
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number31
DOIs
Publication statusPublished - Jul 30 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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