Enantioselective carboxylation of α-methoxybenzyllithium generated via asymmetric lithiation with a t-BuLi/chiral bis(oxazoline) complex

Nobuyuki Komine, Lan Fang Wang, Katsuhiko Tomooka, Takeshi Nakai

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41 Citations (Scopus)

Abstract

Treatment of benzyl methyl ether with a t-BuLi/chiral bis(oxazoline) complex followed by carboxylation is shown to afford α-methoxy phenylacetic acid in high % ee (up to 95%). The asymmetric induction was proved to occur at the post-lithiation step.

Original languageEnglish
Pages (from-to)6809-6812
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number37
DOIs
Publication statusPublished - Sep 10 1999
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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