Enantioselective incorporation of azobenzenes into oligodeoxyribonucleotide for effective photoregulation of duplex formation

Hiroyuki Asanuma, Tohru Takarada, Takayuki Yoshida, Daisuke Tamaru, Xingguo Liang, Makoto Komiyama

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

A drop in melting point of 21.5°C is induced by the UV-photolytic trans→cis isomerization of the duplex formed between an oligonucleotide bearing two D-threoninol-tethered azobenzene moieties (see picture) in the side chain and its complementary counterpart. On irradiation with visible light, the dissociated single-stranded oligonucleotides regenerate the duplex.

Original languageEnglish
Pages (from-to)2671-2673
Number of pages3
JournalAngewandte Chemie - International Edition
Volume40
Issue number14
DOIs
Publication statusPublished - Jul 16 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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